- Synthesis of polysubstituted furans from aryl gem-dibromoethenes
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[Figure not available: see fulltext.] Synthesis of 2,3,5-trisubstituted furans can be performed at 120°C in DMF using aryl gem-dibromoethenes and ethyl acetoacetate as the starting substrates under the assistance of Ag2CO3–Cs2/
- Zhang, Wensheng,Xu, Wenjing
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p. 615 - 617
(2017/08/30)
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- Copper-Mediated [3 + 2] Oxidative Cyclization Reaction of N-Tosylhydrazones and β-Ketoesters: Synthesis of 2,3,5-Trisubstituted Furans
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The first attempt at utilizing N-tosylhydrazones as two-carbon synthons has been successfully achieved, which underwent a copper-mediated [3 + 2] oxidative cyclization reaction to afford 2,3,5-trisubstituted furans in moderate to good yields. The features of this method include inexpensive metal catalyst, readily available substrates, high regioselectivity, and convenient operation. The studies provide important approaches for further exploration of the powerful and diverse reaction abilities of N-tosylhydrazones.
- Huang, Yubing,Li, Xianwei,Yu, Yue,Zhu, Chuanle,Wu, Wanqing,Jiang, Huanfeng
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p. 5014 - 5020
(2016/07/06)
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- Tuning radical reactivity using iodine in oxidative C(sp3)-H/C(sp)-H cross-coupling: An easy way toward the synthesis of furans and indolizines
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Molecular iodine was found to be an effective redox catalyst for the oxidative cross-coupling of carbonyl compounds with terminal alkynes. In this work, we demonstrated that iodine could tune radical reactivity through reversible C-I bond formation for co
- Tang, Shan,Liu, Kun,Long, Yue,Qi, Xiaotian,Lan, Yu,Lei, Aiwen
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supporting information
p. 8769 - 8772
(2015/05/20)
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- Silver-mediated oxidative C-H/C-H functionalization: A strategy to construct polysubstituted furans
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A novel silver-mediated highly selective oxidative C-H/C-H functionalization of 1,3-dicarbonyl compounds with terminal alkynes for the creation of polysubstituted furans and pyrroles in one step has been demonstrated. Promoted by the crucial silver specie
- He, Chuan,Guo, Sheng,Ke, Jie,Hao, Jing,Xu, Huan,Chen, Hongyi,Lei, Aiwen
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supporting information; experimental part
p. 5766 - 5769
(2012/05/07)
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- One-pot synthesis of furans using base- and acid-supported reagents Na 2CO3/Al2O3-PPA/SiO2'
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A convenient method for the one-pot synthesis of furans from -keto esters and -halo ketones was developed using an acid- and base-supported reagent system Na2CO3/Al2O3-PPA/SiO2'. The condensation reaction of triketones, which are formed from the reaction of -keto esters with -halo ketones in the presence of Na2CO 3/Al2O3, was promoted by PPA/SiO2 to give the corresponding furans in good yields. This method is simple and easy to perform in comparison with stepwise processes, and the yields are good.
- Aoyama, Tadashi,Nagaoka, Takashi,Takido, Toshio,Kodomari, Mitsuo
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experimental part
p. 619 - 625
(2011/04/15)
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