Synthesis of optically active methadones, LAAM and bufuralol by lipase-catalysed acylations
(R)- and (S)-Methadones and levo-α-acetylmethadol (LAAM) have been synthesised starting from lipase-catalysed acylation of dimethylaminopropan-2-ol. An approach to the synthesis of (R)-bufuralol is also presented.
Hull, Jonathan D.,Scheinmann, Feodor,Turner, Nicholas J.
p. 567 - 576
(2007/10/03)
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