- The influence of molecular flexibility on the mesogenic behavior of a new homologous series based on azo-azomethine: Synthesis, characterization, photoisomerization and DFT study
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Through condensation of 2-hydroxy-4-n-alkoxybenzaldehyde (n = 2 to 8, 10, 12, 14, 16, 18) with (E)-4-((2,4-dimethylphenyl)diazenyl) benzene-1,3-diamine, new homologous series of rod shaped calamite liquid crystals based on azo-azomethine have been prepared. All synthesized compounds were characterized by FT-IR, 1H NMR, and 13C NMR spectroscopy. Use Differential Scanning Calorimeter (DSC) and Polarizing Optical Microscope (POM) to check the liquid crystal properties of all synthetic compounds. In the homologous series, all the compounds are mesogenic; some of them are in the nematic phase; some of them appear in the smectic A phase, and some appear in the nematic and smectic A phases. UV–vis pectroscopy was used to study the photoisomerization in chloroform. DFT (Density functional theory) level calculations and complete geometric optimization of all synthetic compounds are performed using B3LYP/6-31+G (d, p) basis sets.
- Jadeja, Rajendrasinh N.,Katariya, Kanubhai D.,Nakum, Kiran J.,Savani, Chirag J.
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- Coumarin sulfonamides and amides derivatives: Design, synthesis, and antitumor activity in vitro
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Coumarins possesses immeasurable antitumor potential with minimum side effects depending on the substitutions on the basic nucleus, which exhibits great prospects for antitumor drug development. In an attempt to develop novel antitumor candidates, a series of coumarin sulfonamides and amides derivatives were designed and synthetized. The majority of these derivatives showed good cytotoxic activity against MDA-MB-231 and KB cell lines, among which compound 9c was the most potent against MDA-MB-231 cells, with IC50 value of 9.33 μM, comparable to 5-fluorouracil. Further investigation revealed that compound 9c had versatile properties against tumors, including inhibition of cell migration and invasion as well as inducing apoptosis. Reactive oxygen species (ROS) assay and western blotting analysis suggested that compound 9c promoted cancer cell apoptosis by increasing ROS levels and upregulating the expression of caspase-3 in MDA-MB-231 cells. These results indicated that compound 9c could be promising lead compound for further antitumor drug research.
- Chen, Lexian,Ji, Hong,Li, Guorong,Nie, Minyi,Tan, Yaling,Wang, Zhaohua,Zhang, Jing
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- Synthesis, characterization, and mesomorphic properties of some new Schiff base homologues series and their Cu(II) complexes
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In present study, we have synthesized two homologous series of some new Schiff base of 4-n-alkoxy-2-hydroxy benzaldehyde (n = 2–8, 10, 12, 14, 16, 18) with 4-amino acetanilide and their corresponding Cu(II) complexes. A series of new Schiff base containing two aromatic rings have been synthesized and characterized by various spectroanalytical techniques including FT-IR and 1H NMR. The mesomorphic properties of these compounds were observed by optical polarized light microscopy (POM) and confirmed by differential scanning calorimetry (DSC) study. It has been observed that all the newly synthesized compounds exhibit wide range SmA phase.
- Nakum, Kiran J.,Katariya, Kanubhai D.,Jadeja, Rajendrasinh N.
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- METHODS OF TREATING CANCER WITH SMALL MOLECULE NF-kB INHIBITORS
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The present invention provides, inter alia, compounds capable of inhibiting NF-κB. Pharmaceutical compositions containing and methods of using the compounds are also provided herein. Also provided are methods and kits for treating cancer and solid tumors in a subject, as well as methods and kits for inducing cancer cell death and apoptosis of a cancer cell, all utilizing the NF-κB inhibitors described herein.
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Paragraph 0429
(2019/01/15)
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- Schiff base of 4-n-alkoxy-2-hydroxy benzaldehyde with 4-amino acetophenone and their Cu(II) complexes: synthesis, characterization and mesomorphic behavior
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New homologous series of Schiff’s base of 4-n-Alkoxy-2-hydroxy benzaldehyde (n = 2 to 8, 10, 12, 14, 16, 18) with 4-amino acetophenone and their Cu(II) metal complexes have been synthesized. The compounds were characterized using various spectroscopic techniques including FT-IR, 1H-NMR, 13C-NMR. Mesomorphic properties of these compounds have been investigated with polarizing optical microscope and differential scanning calorimeter. These compounds exhibit wide range SmA phase as confirmed by their typical optical texture under polarizing microscope.
- Nakum, Kiran J.,Katariya, Kanubhai D.,Jadeja,Prajapati
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- Choline hydroxide: An efficient and biodegradable catalyst for the synthesis of 2-amino-3-nitro-4H-chromene derivatives in an aqueous medium
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An expedient, eco-friendly and efficient procedure for the synthesis of novel 2-amino-3-nitro-4H-chromene derivatives has been developed through the reaction of various 2-hydroxybenzaldehydes and (E)-N-methyl-1-(methylthio)-2-nitroethenamine in the presence of the basic ionic liquid catalyst (choline hydroxide (ChOH)) at room temperature an aqueous medium. The advantageous of this method is a biodegradable and recyclable catalyst, mild, environmentally friendly and high products yields (83-96%) in short reaction times.
- Krishnammagari, Suresh Kumar,Lim, Kwon Taek,Cho, Byung Gwon,Tae Jeong, Yeon
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supporting information
p. 574 - 581
(2018/09/25)
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- SMALL MOLECULE NF-kB INHIBITORS
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The present invention provides, inter alia, compounds capable of inhibiting NF-κB. Pharmaceutical compositions containing and methods of using the compounds are also provided herein.
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Paragraph 0119
(2017/07/14)
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- Molecular modeling and snake venom phospholipase A2 inhibition by phenolic compounds: Structure-activity relationship
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In our earlier study, we have reported that a phenolic compound 2-hydroxy-4-methoxybenzaldehyde from Janakia arayalpatra root extract was active against Viper and Cobra envenomations. Based on the structure of this natural product, libraries of synthetic structurally variant phenolic compounds were studied through molecular docking on the venom protein. To validate the activity of eight selected compounds, we have tested them in in vivo and in vitro models. The compound 21 (2-hydroxy-3-methoxy benzaldehyde), 22 (2-hydroxy-4-methoxybenzaldehyde) and 35 (2-hydroxy-3-methoxybenzylalcohol) were found to be active against venom-induced pathophysiological changes. The compounds 20, 15 and 35 displayed maximum anti-hemorrhagic, anti-lethal and PLA2 inhibitory activity respectively. In terms of SAR, the presence of a formyl group in conjunction with a phenolic group was seen as a significant contributor towards increasing the antivenom activity. The above observations confirmed the anti-venom activity of the phenolic compounds which needs to be further investigated for the development of new anti-snake venom leads.
- Alam, Md. Iqbal,Alam, Mohammed A.,Alam, Ozair,Nargotra, Amit,Taneja, Subhash Chandra,Koul, Surrinder
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p. 209 - 219
(2016/03/22)
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- MICROBIOCIDALLY ACTIVE BENZOXABOROLES
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Compounds of formula (I) are as defined in the claims, and their use in compositions and methods for the control and/or prevention of microbial infection, particularly fungal infection, in plants and to processes for the preparation of these compounds.
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Page/Page column 54
(2015/09/22)
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- Aldehyde-Assisted Ruthenium(II)-Catalyzed C-H Oxygenations
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Versatile ruthenium(II) complexes allow for site-selective C-H oxygenations with weakly-coordinating aldehydes. The challenging C-H functionalizations proceed with high chemoselectivity by rate-determining C-H metalation. The new method features an ample substrate scope, which sets the stage for the step-economical preparation of various bioactive heterocycles.
- Yang, Fanzhi,Rauch, Karsten,Kettelhoit, Katharina,Ackermann, Lutz
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supporting information
p. 11285 - 11288
(2016/02/18)
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- Aggregation properties of bis(salicylaldiminato)zinc(ii) Schiff-base complexes and their Lewis acidic character
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The synthesis, characterization, 1H NMR, optical absorption and fluorescent properties of a series of amphiphilic Schiff-base bis(salicylaldiminato)zinc(ii) complexes are reported. Detailed 1H NMR, DOSY NMR, optical absorption and fluorescence spectroscopy studies indicate the existence of aggregate species in solutions of non-coordinating solvents. The degree of aggregation is related to the nature of the bridging diamine. Chloroform solutions of complexes where the bridging diamine contains a naphthalene or the pyridine nucleus are always characterized by the presence of defined dimer aggregates, whereas oligomeric aggregates are likely formed by complexes where the bridging diamine contains a benzene ring. In coordinating solvents or in the presence of coordinating species, a complete deaggregation of the complexes occurs, because of the axial coordination to the ZnII ion, accompanied by considerable changes in the 1H NMR and optical absorption spectra. The effect of the alkyl chains length seems to play a minor role in the aggregation properties, as noticed by 1H NMR data, optical absorption and fluorescence spectra, which remain almost unaltered on changing the chain length.
- Consiglio, Giuseppe,Failla, Salvatore,Finocchiaro, Paolo,Oliveri, Ivan Pietro,Bella, Santo Di
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experimental part
p. 387 - 395
(2012/02/05)
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- Rare-earth-containing magnetic liquid crystals
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Rare-earth-containing metallomesogens with 4-alkoxy-N-alkyl-2- hydroxybenzaldimine ligands are reported. The stoichiometry of the complexes is [Ln(LH)3(NO3)3], where Ln is the trivalent rare-earth ion (Y, La, and Pr to Lu, except Pm) and LH is the Schiff base. The Schiff base ligands are in the zwitterionic form and coordinate through the phenolic oxygen only. The three nitrate groups coordinate in a bidentate fashion. The X-ray single- crystal structures of the nonmesogenic homologous complexes [Ln(LH)3(NO3)3], where Ln = Nd(III), Tb(III), and Dy(III) and LH = CH3OC6H3(2-OH)CH=NC4H9, are described. Although the Schiff base ligands do not exhibit a mesophase, the metal complexes do (SmA phase). The mesogenic rare-earth complexes were studied by NMR, IR, EPR, magnetic susceptibility measurements, X-ray diffraction, and molecular modeling. The metal complexes in the mesophase have a very large magnetic anisotropy, so that these magnetic liquid crystals can easily be aligned by an external magnetic field.
- Binnemans, Koen,Galyametdinov, Yury G.,Van Deun, Rik,Bruce, Duncan W.,Collinson, Simon R.,Polishchuk, Arkadiy P.,Bikchantaev, Ildar,Haase, Wolfgang,Prosvirin, Andrey V.,Tinchurina, Larisa,Litvinov, Igor,Gubajdullin, Ajdar,Rakhmatullin, Ajdar,Uytterhoeven, Koen,Van Meervelt, Luc
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p. 4335 - 4344
(2007/10/03)
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- Liquid Crystalline Properties of o-Hydroxy Substituted Schiff's Bases and their Copper (II) and Palladium (II) Complexes
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The synthesis and liquid crystalline properties of thirty nine compounds are reported.These include a homologous series of N-(2-hydroxy-4-n-alkoxybenzylidene)-4''-n-dodecylphenylanilines and their corresponding copper (II) and palladium (II) complexes.Differential scanning calorimetry and optical microscopy were used to characterise the mesophases.The Schiff's bases exhibit polymesomorphism while their metal chelates basically show smetic A (SA) and smetic C (SC) phases except for a few derivatives.The transition temperatures of the metal chelates are considerably higher than the ligands from which they are derived.A comparison of the mesomorphic properties of the copper chelates with those of biscopper (II) complexes have also been made.Though the melting points of copper (II) and their corresponding palladium (II) chelates of many homologues are comparable, the clearing points of the latter are consistently higher. - Keywords: Schiff's bases, chelates, smectic A, smectic C
- Prasad, Veena,Sadashiva, B. K.
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p. 303 - 312
(2007/10/02)
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