cas 43064-12-6, 4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride | Articles data ｜lookchem

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43064-12-6

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POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS
The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.
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Page/Page column 42

(2018/07/29)

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists
A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor studied to determine whether either series showed noteworthy agonist activity. Structure-activity relationships were developed from the performed receptor binding assays and functional studies, and the results of the analysis are presented herein.
Conway, Richard J.,Valant, Celine,Christopoulos, Arthur,Robertson, Alan D.,Capuano, Ben,Crosby, Ian T.
p. 2560 - 2564
(2012/05/05)

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Chemical Properties

Appearance/Colour :light brown powder
Melting Point: 202-203.5 °C(lit.)
Boiling Point: 267.9oC at 760 mmHg
Flash Point:119.9oC
Solubility:Chloroform (Sparingly), Methanol (Slightly)
Storage Temp.:Inert atmosphere,Room Temperature
Vapor Pressure: 0.00792mmHg at 25°C
PSA: 12.03000
LogP: 3.19410

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