Aromatic C-F activation at Ni in the presence of a carbon-chlorine bond: The nickel mediated synthesis of new pyrimidines
Treatment of [Ni(COD)2]/PCy3 with 5-chloro-2,4,6-trifluoropyrimidine affords the C-F activation product trans-[NiF(4-C4N2ClF2)(PCy3) 2] 2, which reacts with iodine to form 5-chloro-2,6-difluoro-4-iodo-pyrimidine 5.