- Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination
-
Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.
- Du, Yi-Dan,Chen, Bi-Hong,Shu, Wei
-
supporting information
p. 9875 - 9880
(2021/03/29)
-
- Non-cryogenic CeCl3-promoted double additions of methyllithium and n-butyllithium to unsaturated nitriles
-
Subjection of methyl or n-butyllithium to a mixture of nitriles and activated cerium chloride in THF at -10 to 0 °C afforded the corresponding carbinamines, which were isolated as either the hydrochloride salts or acetamide or benzamide derivatives in 30-91% yields. Georg Thieme Verlag Stuttgart.
- Limanto, John,Dorner, Benjamin,Devine, Paul N.
-
p. 4143 - 4150
(2008/03/13)
-