- METHOD AND CATALYST FOR PREPARING ANILINE COMPOUNDS AND USE THEREOF
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The present invention provides a method for preparing aniline compounds, and also provides a kind of catalyst and use thereof. This method for synthesizing an aniline compound in the invention includes following steps: use molybdenum oxide and activated carbon as catalyst, hydrazine hydrate as reducing agent, then reduce aromatic nitro compounds to aniline compounds. This method is green and high efficiency, and easy to be applied in industry.
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Paragraph 0062-0063
(2019/04/18)
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- Method for synthesizing aniline compound, catalyst and application thereof
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The invention provides a method for synthesizing an aniline compound, and further provides a catalyst and an application thereof. The method for synthesizing the aniline compound includes the following steps: taking molybdenum-based oxide and activated carbon as catalysts; taking hydrazine hydrate as a reducing agent; and reducing an aromatic nitro compound to the aniline compound. The method forsynthesizing the aniline compound has the characteristics of green and high efficiency, easy industrial application and the like.
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Paragraph 0066; 0067
(2019/04/17)
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- Changes in the activity and selectivity of herbicides by selective fluorine substitution, taking bentranil and classic analogues as examples
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The introduction of fluorine atoms into 2-phenyl-4H-3,1-benzoxazin-4-one (bentranil) led to sweeping changes in its herbicidal properties in some cases, and 5-fluoro-2-phenyl-4H-3,1-benzoxazin-4-one ('fluorobentranil') was found to be the most active compound. It can be prepared from 2-amino-6-fluoro-benzoic acid or by direct halogen exchange of 5-chloro-2-phenyl-4H-3,1-benzoxazin-4-one. The latter reaction was investigated on a pilot scale, including a high-temperature (350°C) potassium fluoride halogen exchange without solvent. When sulfolane was used as a solvent, a side reaction at 220°C - partial decomposition to a diphenylether - could be prevented by addition of a small amount of a radical scavenger. Other intermediates with a pseudohalogen substitution were obtained by side-chain chlorination of suitable methylsulfanyl benzoic acid precursors and halogen exchange. 'Fluorobentranil' shows good broad-leaf activity and selectivity on rice, cereals and maize. In a second case study, the fluoro-substituted anthranilic acids mentioned above were also found to be appropriate for synthesizing herbicidal sulfonylurea (SU) compounds via Meerwein reaction of their aniline function. Methyl 2-[({[(4-chloro-6-methoxy-2- pyrimidinyl)-amino]carbonyl}amino)sulfonyl]-6-fluorobenzoate is an example of a SU that is compatible with maize, whereas the unsubstituted Classic analogue is not selective.
- Hamprecht, Gerhard,Wuerzer, Bruno,Witschel, Matthias
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p. 117 - 122
(2007/10/03)
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- Tripler stability of oligodeoxynucleotides containing substituted quinazoline-2,4-(1H,3H)-dione
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Triple helical structures can be observed between double-stranded nucleic acids and a third strand through the formation of Hoogsteen hydrogen bond. We report here the use of quinazoline-2,4-dione derivatives as substitutes for thymine in TA*T triplets. The synthesis and the characterization of monochloro derivatives of quinazoline-2,4-dione as well as 5-fluoro and 6-nitro substituted quinazoline rings are described. The ability of the various modified bases to promote the formation of triplexes was reached by thermal denaturation studies.
- Michel, Justine,Gueguen, Genevieve,Vercauteren, Joseph,Moreau, Serge
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p. 8457 - 8478
(2007/10/03)
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- AN IMPROVED PROCEDURE FOR THE SYNTHESIS OF 3-FLUOROANTHRANILIC ACID
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3-Ffluoroanthranilic acid is derived in four steps from 3-nitrophthalic acid in 53percent overall yield.
- Milner, David J.
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p. 485 - 490
(2007/10/02)
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- Preparation of fluorinated anthranilic acid and anthranilonitrile
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Fluorinated anthranilic acid and anthranilonitrile, and a novel process for their preparation by reacting 2,6-difluorobenzonitrile with ammonia and, if the acid is required, hydrolyzing the resulting 6-fluoroanthranilonitrile with a basic compound. The two novel end products are valuable intermediates for the preparation of compounds which are useful for controlling various animal pests and plant pests.
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