- Sustainable organophosphorus-catalysed Staudinger reduction
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A highly efficient and sustainable catalytic Staudinger reduction for the conversion of organic azides to amines in excellent yields has been developed. The reaction displays excellent functional group tolerance to functionalities that are otherwise prone to reduction, such as sulfones, esters, amides, ketones, nitriles, alkenes, and benzyl ethers. The green nature of the reaction is exemplified by the use of PMHS, CPME, and a lack of column chromatography.
- Lenstra, Danny C.,Lenting, Peter E.,Mecinovi?, Jasmin
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supporting information
p. 4418 - 4422
(2018/10/17)
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- GLUCOSE SENSOR MOLECULE
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The present invention provides a glucose sensor having a glucose receptor containing a binding site of formula (I): wherein X, n, m and R1 are defined herein. Also provided is a glucose sensor molecule for use in such a glucose sensor, the glucose sensor molecule containing the binding site of formula (I). The binding site has been found to have particularly good selectivity for glucose.
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Page/Page column 17
(2012/07/28)
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- N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES
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The invention relates to compound of the formula I in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.
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Page/Page column 70
(2012/02/15)
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- One- and two-photon live cell imaging using a mutant SNAP-Tag protein and its FRET substrate pairs
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A small molecule-assisted protein labeling strategy based on a mutant SNAP-Tag (mSNAP) and its FRET substrate pairs has been developed. Both one- and two-photon fluorescence microscopic experiments were successfully demonstrated in living cells.
- Zhang, Chong-Jing,Li, Lin,Chen, Grace Y. J.,Xu, Qing-Hua,Yao, Shao Q.
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supporting information; experimental part
p. 4160 - 4163
(2011/10/09)
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- Derivatives of squaric acid with anti-proliferative activity
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The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers and isomers thereof, as a single stereoisomer or a mixture of stereoisomers, or as a pharmaceutically acceptable sa
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Page/Page column 26
(2008/12/08)
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- Derivatives of squaric acid with anti-proliferative activity
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The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers thereof, as a single stereoisomer or a mixture of stereoisomers, or as a pharmaceutically acceptable salt thereof.
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Page/Page column 37
(2008/06/13)
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- Synthesis of new AB2 monomers for polymerization to hyperbranched polymers by 1,3-dipolar cycloaddition
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A number of AB2 monomers containing either one azide and two acetylene functions or vice versa have been prepared. Upon polymerization, these compounds were found to give rise to hyperbranched oligomers as detected by NMR spectroscopy. However, the formation of high-molecular-weight polymers could not be proven by GPC analysis. Crosslinking was found to be a major drawback of this approach to hyperbranched polymers. Two examples of the interesting situation in which the polymerization already starts during the introduction of the polymerizable group are described.
- Smet, Mario,Metten, Kris,Dehaen, Wim
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p. 1097 - 1108
(2007/10/03)
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