- Unusual products from dirhodium tetraacetylate-catalyzed decomposition of diazoacetylcycloalkanes
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Rh2(OAc)4-assisted decompositions of diazoacetylcycloalkanes are shown to yield cycloalkylacetic acids (Wolff rearrangement), unexpected cycloalkylcarboxylic acids and bicyclic ketones (intramolecular C-H bond insertion). Rh2(OCOF3)4-promoted reactions, on the other hand, have furnished bicyclic ketones and ketene dimers.
- Ceccherelli, Paolo,Curini, Massimo,Marcotullio, Maria Carla,Pisani, Emanuela,Rosati, Ornelio,Wenkert, Ernest
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p. 8501 - 8506
(2007/10/03)
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- POTENTIAL CEREBRAL STIMULANTS: ESTERS OF 2-DIMETHYLAMINOETHANOL WITH SOME LIPOPHILIC CARBOXYLIC ACIDS
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2-Dimethylaminoethyl esters of 2,2-dimethylpropanoic, heptanoic, octanoic, decanoic, hexadecanoic, cyclopentylacetic, cycloheptylacetic, 2-cyclopenthylhexanoic, (4-chlorophenoxy)fumaric, and 2-(4-chlorophenoxy)succinic acid were prepared by reactions of the acid chlorides with 2-dimethylaminoethanol and were transformed to crystalline salts for pharmacological testing.The ester IX (hydrogen fumarate VUFB-14005) was found to antagonize significantly halothan amnesia in rats and the ester X (hydrogen fumarate VUFB-14004) proved to be an anticholinergic spasmolytic agent.
- Protiva, Miroslav,Valenta, Vladimir,Kopicova, Zdenka,Lukac, Juraj,Holubek, Jiri,Krejci, Ivan
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p. 1278 - 1289
(2007/10/02)
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- Dicarboxylic acids and derivatives
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Benzocycloalkenderivatives substituted in 1-position by carboxyl and carboxyalkyl or two carboxyl groups, and further substituted in the benzene ring by cycloalkyl and optionally other substituents, their esters, amides and pharmaceutically acceptable sal
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