cas 442-52-4, Clemizole | Articles data ｜lookchem

Welcome to LookChem.com Sign In|Join Free

Article Database

Home > CAS Article list >
442-52-4

Articles about 442-52-4Total 4 be found

Article title
Article abstract
Author
Journal number and time
Download

Metal-Free Aminomethylation of Aromatic Sulfones Promoted by Eosin Y
A metal-free α-aminomethylation of heteroaryls promoted by eosin Y under green light irradiation is reported. A large variety of α-trimethylsilylamines as precursor of α-aminomethyl radical species were engaged to functionalize sulfonyl-heteroaryls following a Homolytic Aromatic Substitution (HAS) pathway. This method has provided a range of α-aminoheteroaryl compounds including a functionalized natural product. The mechanism of this late-stage functionalization of aryls was investigated and suggests the formation of a sulfonyl radical intermediate over a reductive quenching cycle.
Thierry, Thibault,Pfund, Emmanuel,Lequeux, Thierry
p. 14826 - 14830
(2021/10/01)

Hypervalent iodine-mediated synthesis of benzoxazoles and benzimidazoles via an oxidative rearrangement
A Beckmann-type rearrangement of o-hydroxy and o-aminoaryl N-H ketimines has been developed to prepare benzoxazoles and N-Ts benzimidazoles, respectively. The ketimine derivatives were easily prepared by condensation of ammonia with the corresponding ketones and (diacetoxyiodo)benzene was found to act as an efficient oxidant to trigger the [1,2]-aryl migration towards the formation of the desired heterocycles. Depending on the substitution pattern, the results revealed another mechanistic pathway through which benzisoxazoles or 1H-indazoles could be formed. The Beckmann-type rearrangement strategy was applied to the synthesis of benzimidazole-containing biorelevant targets such as chlormidazole and clemizole.
Zhang, Xiaohui,Huang, Ruofeng,Marrot, Jér?me,Coeffard, Vincent,Xiong, Yan
p. 700 - 708
(2015/02/02)

Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position
Several analogs based on the lead structure of 1-(4-chlorobenzyl)-2- (pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole) were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). Many of the compounds were found to be potent and highly s
Vlahakis, Jason Z.,Vukomanovic, Dragic,Nakatsu, Kanji,Szarek, Walter A.
p. 6788 - 6795
(2013/10/22)

BENZIMIDAZOLE MODULATORS OF H1 RECEPTOR AND/OR NS4B PROTEIN ACTIVITY
The present invention relates to new benzimidazole modulators of H1 receptor activity and/or inhibitors of NS4B protein activity, pharmaceutical compositions thereof, and methods of use thereof formula (I).
-
Page/Page column 30-31

(2010/11/03)

More Articles about upstream products of 442-52-4

More Articles about downstream products of 442-52-4

Chemical Properties

Melting Point: 239-241℃
Boiling Point: 506.1°Cat760mmHg
Flash Point:259.9°C
Density: 1.25g/cm³
Solubility:insoluble in H2O; ≥16.2 mg/mL in DMSO; ≥95.8 mg/mL in EtOH
Vapor Pressure: 2.29E-10mmHg at 25°C
PSA: 21.06000
LogP: 4.27170

Show more

Global suppliers and manufacturers of 442-52-4total 41 suppliers on LookChem

Company Name
Business Type
Min Order
FOB Price
Main Products
Contact

Dayang Chem (Hangzhou) Co.,Ltd.
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:USD $ 3.0-3.0 / Kilogram
Main Products:993
Country:

Hebei Nengqian Chemical Import and Export Co., LTD
Business Type:Trading Company
Min Order:1 Kilogram
FOB Price:USD $ 9.0-99.0 / Kilogram
Main Products:161
Country:

Henan Tianfu Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:No Data
Main Products:67
Country:

Zhuozhou Wenxi import and Export Co., Ltd
Business Type:Trading Company
Min Order:1 Kilogram
FOB Price:USD $ 139.0-210.0 / Kilogram
Main Products:1
Country:

Baoji Guokang Healthchem co.,ltd
Business Type:Trading Company
Min Order:1 Kilogram
FOB Price:USD $ 10.0-10.0 / Kilogram
Main Products:41
Country:

Taizhou Crene Biotechnology co.ltd
Business Type:Lab/Research institutions
Min Order:100 Milligram
FOB Price:No Data
Main Products:16
Country:

Shanghai Massive Chemical Technology Co., Ltd.
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:USD $ 1.0-1.0 / Gram
Main Products:5
Country:

Zibo Hangyu Biotechnology Development Co., Ltd
Business Type:Lab/Research institutions
Min Order:10 Gram
FOB Price:USD $ 100.0-100.0 / Gram
Main Products:3497
Country:

Xiamen Jenny Chemical Technology Co., Ltd.
Business Type:Trading Company
Min Order:1 Milligram
FOB Price:No Data
Main Products:33
Country:

Shandong Mopai Biotechnology Co., LTD
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:No Data
Main Products:60
Country:

Hunan chemfish Pharmaceutical co.,Ltd
Business Type:Manufacturers
Min Order:No Data
FOB Price:No Data
Main Products:29
Country:

ACHIEVER SYSTEAM BIOCHEM CO., LTD.
Business Type:Lab/Research institutions
Min Order:100 Gram
FOB Price:USD $ 1.0-1.0 / Gram
Main Products:24
Country:

SAGECHEM LIMITED
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:33
Country:

GIHI CHEMICALS CO.,LIMITED
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:80
Country:

Sinoway Industrial Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:105
Country:

Shanghai Acmec Biochemical Technology Co., Ltd.
Business Type:Lab/Research institutions
Min Order:1 bottle
FOB Price:No Data
Main Products:30
Country:

Henan Allgreen Chemical Co.,Ltd
Business Type:Manufacturers
Min Order:No Data
FOB Price:No Data
Main Products:34
Country:

Hangzhou Huarong Pharm Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:68
Country:

Antimex Chemical Limied
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:163
Country:

Guangdong Juda Chemical Industrial Co.,Limited
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:30
Country:

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 442-52-4

About us - Payment - Contact us - Links - Help Center - Disclaimer
SiteMap | Manufacturers | VIP Product | Suppliers | CAS | New CAS | Cas Database | Article Data | Chemical Catalog | Product Name

©2008 LookChem.com,License:ICP NO.:Zhejiang16009103 complaints:service@lookchem.com
[Hangzhou]86-571-87562588,87562561,87562573 Our Legal adviser: Lawyer