cas 443-31-2, 6-hydroxytryptamine | Articles data

Articles about 443-31-2Total 4 be found

Preparation method of 6-hydroxyindole derivative
The invention discloses a preparation method of a 6-hydroxyindole derivative tert-butyl 2-(6-hydroxy-1H-indole-3-yl)ethylcarbamic acid. A desired product is prepared from 6-hydroxyindole as a starting material through a Friedel-Crafts reaction, an amidation reaction, a reduction reaction and a tert-butoxycarbonyl protection reaction. The compound is an important pharmaceutical intermediate.
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Paragraph 0025; 0026

(2018/01/12)

Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors
Haspin is a serine/threonine kinase that phosphorylates Thr-3 of histone H3 in mitosis that has emerged as a possible cancer therapeutic target. High throughput screening of approximately 140,000 compounds identified the beta-carbolines harmine and harmol as moderately potent haspin kinase inhibitors. Based on information obtained from a structure-activity relationship study previously conducted for an acridine series of haspin inhibitors in conjunction with in silico docking using a recently disclosed crystal structure of the kinase, harmine analogs were designed that resulted in significantly increased haspin kinase inhibitory potency. The harmine derivatives also demonstrated less activity towards DYRK2 compared to the acridine series. In vitro mouse liver microsome stability and kinase profiling of a representative member of the harmine series (42, LDN-211898) are also presented.
Cuny, Gregory D.,Ulyanova, Natalia P.,Patnaik, Debasis,Liu, Ji-Feng,Lin, Xiangjie,Auerbach, Ken,Ray, Soumya S.,Xian, Jun,Glicksman, Marcie A.,Stein, Ross L.,Higgins, Jonathan M.G.
scheme or table
p. 2015 - 2019
(2012/04/05)

Facile synthesis of 6-hydroxyindole-3-acetic acid: On the structure of the aromatic subunit of nephilatoxin-1~6
A facile synthesis of 6-hydroxyindole-3-acetic acid 1a, which is the proposed aromatic subunit of NPTX-1~6, is described. Radical cyclization of isonitrile 2 successfully afforded 9 in high yield. The aromatic subunit of NPTX-1~6 was confirmed as 4-hydroxyindole-3-acetic acid 12 by comparison of the 1H-NMR spectra with those of authentic 4- and 6-hydroxyindole-3-acetic acids.
Shinada, Tetsuro,Miyachi, Miki,Itagaki, Yasuhiro,Naoki, Hideo,Yoshihara, Kazuo,Nakajima, Terumi
p. 7099 - 7102
(2007/10/03)