- 99mTc labeled myocardial imaging agents of long-chain fatty acid: An intermediate synthesis process research
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Myocardial fatty acid metabolic imaging agent can be used for studying the myocardial ischemia positioning, measurements reflect changes in myocardial metabolic function and the detection of myocardial cell survival, provide a reliable basis for the clinical diagnosis of cardiac disease. In this paper, we study the synthesis of fatty brominated products BSE, which is the intermediates of novel 99mTclabeled fatty acid metabolic imaging agent. The final yield of the product was 38 %, NMR spectroscopy confirmed very consistent the hydrogen peak displacement and integral spectrum area with the goal of formula. This synthetic route is convenient, simple, economic and has a potential value of industrial applications.
- Huo, Qing,Xue, Jingquan,Liu, Yu
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- Syntheses and first crystal structures of rhenium complexes derived from ω-functionalized fatty acids as model compounds of technetium tracers for myocardial metabolism imaging
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In an attempt to develop new technetium-based radiopharmaceuticals for the noninvasive diagnosis of myocardial metabolism, we have synthesized three examples of novel metal-containing fatty acid derivatives according to the "3+1 " mixed-ligand and the Schiff base/tricarbonyl design. The chelates contain the metal core in the oxidation states +5 and +1, respectively, and are attached to the end-position of a fatty acid chain. The complex formation was accomplished by ligand-exchange reactions with three different rhenium precursors, whereas the inactive rhenium metal was utilized as a surrogate of the technetium radionuclide. The molecular structures of the fatty acid complexes 7, 10 and 14 were determined by single-crystal X-ray diffraction analyses and impressively show a general problem in technetium tracer research, namely the significant structural alterations of bioactive molecules by coordination even to small metal chelates. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
- Jung, Christian M.,Kraus, Werner,Leibnitz, Peter,Pietzsch, Hans-Juergen,Kropp, Joachim,Spies, Hartmut
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p. 1219 - 1225
(2007/10/03)
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