Synthesis, resolution, and absolute configuration of novel tricyclic benzodiazepines
The synthesis, resolution, and stereochemical characterization of novel piperazino-, thiazino-, and oxazinobenzodiazepines are described. The absolute stereochemistry of the heterotricycles was determined by using X-ray crystallography and the enantiomeri
Matthews, Jay M.,Dyatkin, Alexey B.,Evangelisto, Mary,Gauthier, Diane A.,Hecker, Leonard R.,Hoekstra, William J.,Liu, Fuqiang,Poulter, Brenda L.,Sorgi, Kirk L.,Maryanoff, Bruce E.