Synthesis and biological properties of new 1β-methylcarbapenems
The synthesis and biological activity of the novel series of 1β- methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R2=NH2) showed an excellent and a broad spectrum as well as high renal DHP- I stability. It also possessed good in vivo efficacy and high safety.
Shin, Kye Jung,Yoo, Kyung Ho,Kim, Dong Jin,Park, Sang Woo,Ko, Bong Suck,Lee, Sang Joo,Huh, Jae Doo,Park, Seung Yong
p. 1607 - 1612
(2007/10/03)
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