- N, O-Bidentate ligand-tunable copper(II) complexes as a catalyst for Chan-Lam coupling reactions of arylboronic acids with 1 H-imidazole derivatives
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An efficient procedure for Chan-Lam coupling reactions of arylboronic acids with 1H-imidazole derivatives using N,O-bidentate ligand-tunable copper(ii) complexes as a catalyst under base-free conditions has been developed. This protocol features mild reac
- Jia, Xuefeng,Peng, Pai
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p. 8984 - 8988
(2018/12/10)
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- A New Approach to the Synthesis of 1-Arylbenzimidazole-2-thiones from Nitroarenes and Anilines through Halogen-Free Substitution of Hydrogen via Iminophosphorane Intermediates
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2-(Arylamino)phenyliminophosphoranes, formed directly from 2-nitrosodiarylamines, undergo a high-yielding cyclocondensation with CS2, providing a variety of 1-arylbenzimidazole-2-thiones. The reaction concludes a new synthetic route leading to the title compounds from simple nitroarenes and arylamines. The protocol is superior to common methods that use N-arylarylenediamines because it omits the SNAr substitution of halogen atoms in ortho-halonitroarenes, as well as reduction processes required for the synthesis of the intermediate diamines.
- ?ukasik, Emilia,Wróbel, Zbigniew
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p. 263 - 270
(2016/01/15)
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- Process for making 2-mercapto benzimidazoles in the presence of a water-insoluble alkanol
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A process is provided for making benzimidazoles having the formula STR1 wherein Y is oxygen, sulfur or --NH; R1 is hydrogen, C1 -C12 alkyl, C5 -C6 cycloalkyl, C6 -C10 aryl, C7 -C9 aralkyl or C7 -C9 alkaryl; R2 is hydrogen, C1 -C4 alkyl, C1 -C4 alkoxy or halogen; and n is 1 or 2; comprising reacting a compound having the formula ZYCN, wherein Z is an alkali metal or ammonium moiety and Y has the meanings above; with a compound having the formula STR2 wherein R1, R2 and n have the meanings above, in the presence of a C4 -C10 alkanol and, except when Z is NH4, in the presence of an acid.
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- α-Mercaptophenylacetic acid derivatives of imidazole-containing compounds and analogues thereof
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α-Mercaptobenzylacetic acid derivatives of imidazole-containing compounds and analogues thereof, and their use as immunomodulating agents are disclosed.
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