A simple synthesis of 3,4-dihydrobenzo[f]quinoxalin-6(2H)-one derivatives substituted in the ring B
[Figure not available: see fulltext.] We followed a simple, inexpensive, and efficient route to synthesize a series of 3,4-dihydrobenzo[f]quinoxalin-6(2H)-one derivatives substituted in the ring B, with the expectation that this scaffold might exhibit antineoplastic activity. 5-Chlorobenzo[f]quinoxalin-6-ylacetate and 4-benzylbenzo[f]quinoxalin-6(4H)-one were obtained for the first time.
Angular Heterocycles. A Convenient Synthesis of 6-N-(Acetylanilino)-5H-benzophenothiazin-5-one, 6-N-(Acetylanilino)-5H-benzophenoxazin-5-ones and Their Derivatives
The reaction of 2-N-(acetylanilino)-3-chloro-1,4-naphthoquinone (2) with bifunctional aromatic amines afforded angular heterocycles 6 and 7.Reductive acetylation of 7 provided O-acyl 9 and O,N-diacyl 10 derivatives depending upon the reaction conditions.T
Agarwal, N. L.,Ghosh, S.,Tripathi, A. K.,Atal, C. K.
p. 509 - 512
(2007/10/02)
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