- A Strategy to Construct cis-Hydrocarbazole via Nickel/Lewis Acid Dual-Catalyzed Arylcyanation
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A strategy for the synthesis of cis-hydrocarbazole with a C3 quaternary carbon center has been developed through nickel/Lewis acid dual-catalyzed arylcyanation. A wide array of cis-hydrocarbazoles was accessed with high diastereoselectivities and atom eco
- Chen, Peiqi,Li, Huilin,Ma, Shiqiang,She, Xuegong,Wang, Xiaolei,Wang, Zemin,Xie, Xingang,Yang, Hesi,Zhang, Hao
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- Palladium-catalyzed reductive coupling of phenols with anilines and amines: efficient conversion of phenolic lignin model monomers and analogues to cyclohexylamines
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Phenols, being readily available from naturally abundant lignins, are important future feedstocks for the renewable production of fuels, chemicals, and energy. Herein, a highly efficient Pd-catalyzed direct coupling of phenolic lignin model monomers and analogues with anilines to give cyclohexylamines using cheap and safe sodium formate as hydrogen donor is described. A variety of secondary and tertiary substituted cyclohexylamines can be synthesized under convenient conditions in moderate to excellent yields.
- Chen, Zhengwang,Zeng, Huiying,Gong, Hang,Wang, Haining,Li, Chao-Jun
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p. 4174 - 4178
(2015/06/25)
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- Synthesis of Multiple-Substituted Pyrroles via Gold(I)-Catalyzed Hydroamination/Cyclization Cascade
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A gold-catalyzed cascade hydroamination/cyclization reaction of α-amino ketones with alkynes to form substituted pyrroles has been developed. The method offers several advantages such as high regioselectivity with the tested cases, wide functional group tolerance, and easily accessible starting materials. The synthetic utility of the obtained pyrrole products was demonstrated by their efficient transformations to 2-vinylated pyrroles via gold-catalyzed intermolecular hydroarylation.
- Li, Xiangdong,Chen, Ming,Xie, Xin,Sun, Ning,Li, Shi,Liu, Yuanhong
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p. 2984 - 2987
(2015/06/30)
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- Molecular modeling and anticholinesterasic activity of novel 2-arylaminocyclohexyl N,N-dimethylcarbamates
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This work reports a detailed theoretical and experimental study of the novel isomer series cis- and trans-2-arylaminocyclohexyl N,N-dimethylcarbamates as potential inhibitors of cholinesterases. In vitro inhibition assay by Ellman's method with human bloo
- Bagatin, Mariane C.,Ca?ndido, Augusto A.,Pinheiro, Glaucia M.S.,Ho?ehr, Nelci F.,Machinski Jr., Miguel,Mossini, Simone A.G.,Basso, Ernani A.,Gauze, Gisele F.
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p. 1798 - 1807
(2014/01/06)
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- Development of a generic activation mode: Nucleophilic α-substitution of ketones via oxy-allyl cations
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Oxy-allyl cations have been known as transient electrophilic species since they were first proposed as intermediates in the Favorskii rearrangement in 1894. Since that time, they also have been used as a mode of activation for [4 + 3] cycloadditions in a variety of natural product syntheses. In this manuscript, we describe a method for the interception of oxy-allyl cations with a diverse range of common nucleophiles, thereby demonstrating the value of this intermediate as a generic mode of activation. This simple, mild, room temperature protocol allows for the formation of a variety of high value carbon-carbon and carbon-heteroatom bonds that are readily incorporated within a series of cyclic and acyclic ketone systems. Initial efforts into the development of an enantioselective catalytic variant are also described.
- Vander Wal, Mark N.,Dilger, Andrew K.,Macmillan, David W. C.
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p. 3075 - 3079
(2013/07/26)
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- Synthesis of β-amino cyclone catalyzed by alkaline Al 2O3
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A new method for the synthesis of b-amino cyclone with amines and cyclonene, which was efficiently carried out under solvent free conditions in a short time at room temperature using the catalyst of alkaline Al 2O3 with high yield. T
- Xu,Chen,Liu,Ren,Zhou,Lu
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experimental part
p. 4165 - 4168
(2012/01/05)
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- Highly enantioselective synthesis of chiral cyclic amino alcohols and conhydrine by ruthenium-catalyzed asymmetric hydrogenation
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A highly efficient enantio- and diastereoselective synthesis of chiral cis-β-N-alkyl/arylamino cyclic alcohols has been realized by asymmetric hydrogenation of racemic α-amino cyclic ketones via DKR catalyzed by [RuCl2((S)-Xyl-SDP)((R,R)-DPEN)]. The enantioselectivities of the reaction were up to 99.9% ee with 99:1 cis-selectivities. A practical catalytic asymmetric synthesis of all four isomers of conhydrine was also developed.
- Liu, Sheng,Xie, Jian-Hua,Li, Wei,Kong, Wei-Ling,Wang, Li-Xin,Zhou, Qi-Lin
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supporting information; experimental part
p. 4994 - 4997
(2009/12/28)
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