- Stereoselective Addition of Carboxylic Acids to Electron Deficient Acetylenes Catalyzed by the PdMo3S4 Cubane-Type Cluster
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The mixed-metal sulfide cubane-type cluster complex 3 (1; tacn = 1,4,7-triazacyclononane) was found to be a highly efficient and selective catalyst for the addition of carboxylic acids to acetylenes with electron-withdrawing groups.The corresponding trans addition products were exclusively obtained in good yields under mild reaction conditions in the presence of a catalytic amount of triethylamine.
- Wakabayashi, Takanori,Ishii, Youichi,Murata, Takashi,Mizobe, Yasushi,Hidai, Masanobu
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- Palladium(II)-Catalyzed Three-Component Coupling Reaction Initiated by Acetoxypalladation of Alkynes: An Efficient Route to γ,δ-Unsaturated Carbonyls
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(Matrix Presented) A divalent palladium-catalyzed coupling reaction of electron-deficient alkynes and acrolein or MVK (methyl vinyl ketone) was developed. The reaction provides an efficient method to synthesize γ,δ-unsaturated carbonyls. A mechanism involving acetoxypalladation of alkyne, followed by insertion of alkene and protonolysis of the C-Pd bond, is proposed. The protonolysis of the carbon-palladium bond with the assistance of bidentate nitrogen containing ligands is the key step in this tandem reaction.
- Zhao, Ligang,Lu, Xiyan
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p. 3903 - 3906
(2007/10/03)
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- A novel regio- and stereo-specific hydroacetoxylation reaction of 2-alkynoic acid derivatives
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2-Alkynoic acid derivatives were hydroacetoxylated regio- and stereo-specifically by reaction with lithium acetate in HOAc at rt under the catalysis of palladium acetate to afford 3-acetoxy-2(Z)-alkenoic acid derivatives.
- Lu,Zhu,Ma
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p. 7205 - 7206
(2007/10/02)
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- Trifluoromethyl Substituted 4-Pyrones via Self-condensation of Trifluoroacetoacetates
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When 3-(acetoxy)-4,4,4-trifluoro-2-butenoates 7 and 8 are heated at 100 deg C, in the presence of catalytic amounts of zinc chloride, they undergo self-condensation to yield 2,6-bis(trifluoromethyl)-4-pyrones 1 and 2 respectively.Compounds 1 and 2 were further converted to the corresponding pyridine derivatives 3 and 4 yia ammonolysis.
- Babu, Srinivasan,Pozzo, Mark J.
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p. 819 - 821
(2007/10/02)
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