Additives Based on Liquid Crystal Forming Structure Elements for Suppressing Racemization in Peptide Synthesis by the DCC- and Mixed Anhydrides Methods
A new type of additives suppressing racemization during peptide synthesis by the DCC- and mixed anhydrides methods are liquid crystal forming organic molecules or similar compounds with a specific long chain structure.The suppressing effect of the new additives was followed by the Anderson test, the modifid Young and n.m.r. tests.There was no racemization in a new Leu-enkephalin synthesis by the mixed anhydrides method with azoxybenzene as additive.
Jeschkeit, H.,Strube, M.,Przybylski, J.,Miecznikowska, H.,Kupryszewski, G.
p. 638 - 646
(2007/10/02)
REACTION OF CARBOXYLATE SALTS WITH CYCLIC PHOSPHORAMIDATES : AMIDE BOND FORMATION BY PRIOR AMINE CAPTURE
Tri- or tetraalkyl-ammonium carboxylates react with 2-alkylamino-2-oxo-1,3,2-benzodioxaphospholes at 25 deg C to give amides or peptides, probably by a nucleophilic attack on phosphorous followed by a cascade of intramolecular acyl transfer reaction.
Wakselman, M.,Acher, F.
p. 2705 - 2708
(2007/10/02)
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