- Ni-Catalyzed Aryl Sulfide Synthesis through an Aryl Exchange Reaction
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A Ni-catalyzed aryl sulfide synthesis through an aryl exchange reaction between aryl sulfides and a variety of aryl electrophiles was developed. By using 2-pyridyl sulfide as a sulfide donor, this reaction achieved the synthesis of aryl sulfides without using odorous and toxic thiols. The use of a Ni/dcypt catalyst capable of cleaving and forming aryl-S bonds was important for the aryl exchange reaction between 2-pyridyl sulfides and aryl electrophiles, which include aromatic esters, arenol derivatives, and aryl halides. Mechanistic studies revealed that Ni/dcypt can simultaneously undergo oxidative additions of aryl sulfides and aromatic esters, followed by ligand exchange between the generated aryl-Ni-SR and aryl-Ni-OAr species to furnish aryl exchanged compounds.
- Isshiki, Ryota,Kurosawa, Miki B.,Muto, Kei,Yamaguchi, Junichiro
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supporting information
p. 10333 - 10340
(2021/07/21)
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- Preparation method of sodium o-methylphenoxyacetate in synthesis process of sodium 2-methyl-4-chlorophenoxyacetate
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The invention relates to a preparation method of sodium o-methylphenoxyacetate in a synthesis process of sodium 2-methyl-4-chlorophenoxyacetate. The invention provides a preparation method of sodium o-methylphenoxyacetate, which comprises the following steps of: reacting o-cresol with sodium hydroxide to obtain a sodium o-cresol solution, reacting chloroacetic acid with sodium hydroxide to obtain a sodium chloroacetate solution, and reacting the sodium o-cresol with sodium chloroacetate under the condition of a catalyst to obtain the sodium o-methylphenoxyacetate. The catalyst is added in the preparation process, so that the reaction temperature and the decomposition rate of sodium chloroacetate can be effectively reduced, the conversion rate of o-cresol is improved, the problems of difficulty in later phenol-containing wastewater treatment and high energy consumption caused by low conversion rate of o-cresol are solved, and the preparation process is effectively simplified. Meanwhile, the sodium o-methylphenoxyacetate prepared by the preparation method is relatively high in purity and yield.
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Paragraph 0067-0068; 0072-0090
(2021/08/14)
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- Synthesis of enantiomerically pure 3-aryloxy-2-hydroxypropanoic acids, intermediate products in the synthesis of cis-4-Aminochroman-3-ols
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Oxidation of accessible (R)-3-chloropropane-1,2-diol to (R)-3-chloro-2-hydroxypropanoic acid and subsequent reaction of the latter with ortho-substituted sodium phenoxide gave a number of enantiomerically pure 3-aryloxy-2-hydroxypropanoic acid which are intermediate products in the synthesis of nonracemic 4-aminochroman-3-ols.
- Bredikhina,Pashagin,Kurenkov,Bredikhin
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p. 535 - 539
(2014/06/10)
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- Process for the stereospecific synthesis of indole derivatives
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The present invention relates to a process for the stereo-specific synthesis of indole derivatives of formula: STR1 which consists in using 3-tosyloxy-1,2-O-isopropylidenepropane-1,2-diol (II) in an optically pure form in order to introduce the asymetric carbon C* of compound (I). Compound (II) is condensed with a suitable primary amine in order to prepare an oxazolidinone and condensation with a suitable phenol, and the oxazolidinone ring is then opened to form an indole compound (I).
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- Preparation of alkyl substituted o-hydroxybenzoic acid esters
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A process for producing C1 -C5 alkyl substituted o-hydroxybenzoic acid esters comprising forming an anhydrous alkali metal phenolate-organic carrier mixture, carboxylating the phenolate by contacting the mixture with CO2 and reacting the resultant dialkali metal salt with 1 equivalent of an anhydrous acid/mole of salt and at least 1 mole of C1 -C5 alkyl chloride per mole of salt.
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