- Mercaptooxazole-phenazine based blue fluorescent sensor for the ultra-sensitive detection of mercury(II) ions in aqueous solution
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Herein, a mercury(ii) ion fluorescent sensor (Z-3) with high sensitivity and immediate response is designed and synthesized. The sensor uses the phenazine group as a luminophore and sulfhydryl as a recognition moiety. The sensor is easily synthesized and it exhibits a remarkable blue shift with Hg2+. Correspondingly, its fluorescence color changes from yellow to blue. In addition, the low naked eye detection limit (10-5) of the sensor allows the identification of concentration limits. Moreover, the sensor could detect mercury(ii) ions over a wide pH range (from 2 to 8), which indicates that the detection can be carried out in aqueous systems. In addition, test strips are fabricated, which could act as a convenient pathway for the recognition of Hg2+.
- Zhang, Hai-Li,Li, Wen-Ting,Qu, Wen-Juan,Wei, Tai-Bao,Lin, Qi,Zhang, You-Ming,Yao, Hong
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- Highly selective and sensitive chemosensor based on 2,3-diaminophenazine hydrochloride for the detection of cyanide in pure water and its application in plant seed samples
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In this study, we prepared an efficient chemosensor based on 2,3-diaminophenazine hydrochloride, and it exhibited good dissolvability in water; more importantly, it could act as an efficient chemodosimeter for the selective detection of CN- in pure water. Upon reacting with CN-, 2,3-diaminophenazine hydrochloride (Q1) displayed a remarkable visible and fluorescence response simultaneously with significant changes in both absorption and fluorescence spectra. Furthermore, the absorption and fluorescence detection limits of CN- were 1.95 × 10-7 M and 1.13 × 10-9 M, respectively. For practical applications, test strips based on this chemosensor could serve as convenient CN- detection tools. The chemosensor was also successfully applied to the detection of CN- in plant seeds and several natural water samples.
- Yong, Bi-Rong,Wei, Tai-Bao,Qu, Wen-Juan,Lin, Qi,Zhang, You-Ming,Yao, Hong
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- A self-assembled supramolecular gel constructed by phenazine derivative and its application in ultrasensitive detection of cyanide
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In this work, we constructed a supramolecular gel (PN-G) by phenazine derivative, which can ultrasensitive detect cyanide (detection limit equals to 4.18 × 10?10 M). The decrease of fluorescent intensity displayed a linear relationship in the range of 0–0.4 equivalents of cyanide. And no significant fluorescence quenching was observed for all used interfering ions. The cyanide recognition mechanism of PN-G was verified by XRD, NMR, MS and SEM. With addition of cyanide to the supramolecular gel (PN-G), cyanide broken π-π stacking of PN-G, and then PN-G undergoes a nucleophilic addition reaction with CN?, resulting in fluorescence quenched.
- Fang, Hu,Qu, Wen-Juan,Yang, Hao-Hang,He, Jun-Xia,Yao, Hong,Lin, Qi,Wei, Tai-Bao,Zhang, You-Ming
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- A simple water-soluble phenazine dye for colorimetric/ fluorogenic dual-mode detection and removal of Cu2+ in natural water and plant samples
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Detection and removal of heavy metal ions in a variety of complex water systems using dyes remains a challenge. Here we have developed a rapid, low-cost, on-site water-soluble dye for the colorimetric/fluorogenic detection and removal of copper ions in natural water and plant samples. By comparing with dye molecule AHP, this water-soluble phenazine dye (AHPN) has a high fluorescence quantum yield and excellent coordinated ability with copper ions. AHPN can effectively remove copper ions in various natural water samples due to its strong binding ability with Cu2+. Moreover, the test strips also were fabricated and successfully used for real-time detection of Cu2+ in water with simple-to-use, low-cost, quick response and provide an obvious effect by naked-eye. All data in this experiment showed that this water-soluble phenazine dye AHPN has excellent effect on the detection and removal of Cu2+.
- Wei, Tai-Bao,Yong, Bi-Rong,Dang, Li-Rong,Zhang, You-Ming,Yao, Hong,Lin, Qi
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- Recognition of dihydrogen phosphate ions using the cadmium complex of 2-pyridine-1H-imidazo[4,5-b]phenazine: Utilization of the mechanism of twisted intramolecular charge transfer, long wavelength emission
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A long wavelength emission fluorescent and colorimetric chemosensor with high selectivity for H2PO4- ions was designed and synthesized according to the twisted intramolecular charge transfer (TICT) mechanism. The sensor bears a 2-pyridine-1H-imidazo[4,5-b]phenazine and Cd 2+ metal complex, which showed brilliant fluorescent and colorimetric response for H2PO4- anions in aqueous solution. The detection limit of the sensor towards H2PO 4- is 2.8 × 10-6 M, and other anions, including F-, Cl-, Br-, I-, AcO -, HSO4-, ClO4- and CN-, had nearly no influence on the probing behavior. The test strips based on the 2-pyridine-1H-imidazo[4,5-b]phenazine and Cd2+ metal complex (S2-Cd) were fabricated, which could act as convenient and efficient H2PO4- test kits.
- Shi, Bingbing,Zhang, Youming,Wei, Taibao,Zhang, Peng,Lin, Qi,Yao, Hong
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- Tailoring an HSO4-anion hybrid receptor based on a phenazine derivative
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A catechol-functionalized phenazine imidazole (PD) was tailored with 2,3-diaminophenazine and 3,4-dihydroxy benzaldehyde, and it served as a hybrid acceptor for capturing HSO4- anions. The selectivity and sensitivity of the PD receptor for anion sensing were studied. It was found that the PD receptor could not only display a preferable sensitivity to HSO4- ions with a "turn-off"fluorescence response, but also have a strong anti-interference ability toward other common anions, especially basic anions such as CH3COO-, HPO42-, and H2PO4-. The anion recognition mechanism of PD towards HSO4- is based on multiple hydrogen bond interactions. Finally, the strips for anion detection were prepared, which were verified to be a convenient and high-efficiency test kit for detecting HSO4- ions with the naked eye.
- Qi, Xiao-Ni,Dong, Hong-Qiang,Yang, Hai-Long,Qu, Wen-Juan,Zhang, You-Ming,Yao, Hong,Lin, Qi,Wei, Tai-Bao
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p. 1373 - 1381
(2020/11/03)
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- Water-soluble phenazine derivative as well as preparation method and application thereof
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The invention relates to a water-soluble phenazine derivative as well as a preparation method and an application thereof. The structural formula of the derivative is shown in the specification. The preparation method of the water-soluble phenazine derivative comprises the following steps: adding N, N-dimethylformamide, 2, 3-diaminophenazine, glacial acetic acid and 3, 4-dihydroxy benzaldehyde intoa reactor to obtain the phenazine derivative; in absolute ethyl alcohol, adding phenazine derivatives and sodium hydroxide into the absolute ethyl alcohol, and carrying out a stirring reaction at room temperature to obtain the water-soluble phenazine derivatives. The water-soluble phenazine derivative is used for anion recognition of a silicate ion sensor.
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Paragraph 0027; 0037-0038
(2020/10/29)
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- Mercury ion fluorescent sensor molecule, and synthesis and application thereof
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The invention relates to sensor molecule, 2-sulfydryl-oxazole [4, 5-b] phenazine, capable of performing fluorescence detection on mercury ion. The sensor molecule is prepared through the following steps: taking ethyl alcohol and water as a solvent, KOH as a catalyst and 2-sulfydryl-3-aminophenazine and carbon disulfide as substrates, so as to perform reflux reaction; performing hot suction filtration after reaction, filtering filter liquor after the filter liquor is acidized, performing vacuum drying, and performing DMF recrystallization, so as to obtain yellow green solid namely the mercury ion sensor molecule. The sensor molecule meets Hg2+ in a water-bearing system, hydrogen ion is removed from sulfydryl firstly, then sulfydryl is coordinated with mercury ion, fluorescence becomes lightblue from yellow, and a new emission peak appears in a 492nm position. In addition, mercury ion is added at a room temperature, the fluorescence of solution can rapidly become light blue (smaller than 3 seconds), and a good naked eye identification effect can be achieved. Hg2+ test paper manufactured through the sensor molecule can further conveniently and rapidly detect mercury ion in an environment system.
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Paragraph 0024
(2018/03/26)
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- Sensor molecule for identifying cyanide ions through colorimetric channel and fluorescent channel as well as preparation and application of sensor molecule
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The invention designs and synthesizes a sensor molecule 2-phenyl-1H-imidazole [4, 5-b] phenazine capable of detecting cyanide ions through a colorimetric channel and a fluorescent channel. According to the sensor molecule, firstly, a dimer is formed by an intermolecular hydrogen bond, and then, a supramolecular self-assembly system is formed between phenazine rings according to pi-pi stacking, sothat a host molecule solution is enabled to give out strong fluorescence; after CN- is added, a host has the proton removal action, so that the self-assembly system is crashed to cause fluorescence quenching, the CN- can be identified with high selectivity in a water-bearing medium, and the identification process is not interfered by other negative ions. Additionally, after the CN- is added at room temperature, the fluorescence intensity of the solution is quickly weakened (less than 3s), and the solution becomes jacinth, so that a good naked eye identification effect can be achieved. According to CN-test paper made by adopting the sensor molecule, the cyanide ions in an environmental system can be detected conveniently and fast.
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Paragraph 0031
(2018/03/26)
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- Sensor molecule for recognizing mercury ions with colorimetric fluorometric dual channel as well as synthesis and application thereof
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The invention designs and synthesizes a sensor molecular for recognizing mercury ions with colorimetric fluorometric dual channel, namely 2-cyanomethyl-imidazole[4,5-b]phenazine. The sensor molecule is obtained by adopting normal butanol as a solvent and 2,3-diaminophenazine and ethyl cyanoacetate as a substrate to perform reflux reaction, performing the suction filter after the reaction and vacuum drying. When cation solutions are respectively added into a sensor molecular DMSO-H20 solution, the color of the solution immediately turns light only when Hg is added, the strong yellow fluorescence is completely quenched, so that the sensor molecule can specifically and selectively recognize Hg by virtue of fluorescence in an aqueous solution, the recognition process is not interfered with other cations. In addition, when the mercury ions are added under the room temperature, the fluorescence strength of the solution can be rapidly weakened (less than 3 seconds), and a good naked-eye recognition effect can be achieved. Hg test paper produced by using the sensor molecule can conveniently and rapidly detect the mercury ions in an environmental system.
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Paragraph 0026
(2018/01/11)
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- Pyrano [3,2-a] phenazine derivative, preparation method and application thereof
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The present invention belongs to the technical fields of pharmaceutical chemistry and medicine, and discloses a pyrano [3,2-a] phenazine derivative, a preparation method and application thereof in preparing antineoplastic drugs. The pyrano [3,2-a] phenazine derivative has a structural formula (I), wherein R1 represents H, halogen, -OCH3, or -NO2; R2 represents H, halogen, -OCH3, or -NO2; R3 represents H, -CH3, -C2H5, -CH(CH3)2, halogen, -OH, -OCH3, -N(CH3)2, -N(C2H5)2 or -NO2; R4 represents H, halogen, or -OCH3; R5 represents H, halogen, or -OCH3; and X represents -CN or -COOC2H5. The invention also discloses a preparation method and application of the pyrano [3,2-a] phenazine derivative in the preparation of antineoplastic drugs, the compound has strong inhibition effect on DNA topoisomerase and significant inhibitory activity on a plurality of multiple tumor cell lines, and shows great potential in the preparation of antineoplastic drugs.
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Paragraph 0022; 0023
(2016/10/09)
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- Sliver ion fluorescence sensor molecule as well as synthesis and application thereof
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The invention designs and synthesizes a sliver ion fluorescence sensor molecule-1H-imidazole[4,5-b] phenazine derivative, wherein phenazine in the sensor molecule is a stable system with a rigid structure; the sensor molecule is used as a fluorophore, so that the solution of the main body molecule emits strong fluorescence; imidazole and a furan ring are used as an identifying functional site; and in a water-containing medium, the molecule identifies sliver ions with high selectivity, and the identifying process is not distributed by other positive ions. Besides, when the silver ions are added at the room temperature, the fluorescence intensity of the solution is quickly weakened within 30 seconds, so that a very good naked-eye identifying effect can be achieved. Ag response test paper manufactured by utilizing the sensor molecule also can conveniently and quickly detect the silver irons in an environmental system.
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Paragraph 0033
(2016/10/10)
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- A reversible fluorescent chemosensor for mercury ions based on 1H-imidazo[4,5-b]phenazine derivatives
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A series of non-sulfur, fluorescent sensors (S6, S6-1 or S6-2) for mercury ions bearing 1H-imidazo[4,5-b]phenazine derivatives have been designed and synthesized. Among these sensors, a furan group into the sensor S6 molecule was as the functional group, compound S6-1 containing the 5-(4-Nitrophenyl)-2-furan group was synthesized, and in order to establish the furan group's contribution to the sensor's fluorescent sensing abilities, compound S6-2, which without containing the furan group was also synthesized. S6 showed excellent fluorescent specific selectivity and high sensitivity for Hg2+ in aqueous solution. The detection limit of the sensor towards Hg2+ is 1.6×10-7 M, and other ions, including Fe3+, Ca 2+, Cu2+, Co2+, Ni2+, Cd 2+, Pb2+, Zn2+, Cr3+, and Mg 2+ had nearly no influence on the probing behavior. Notably, this sensor serves as a recyclable component in sensing materials. The test strips based on S6 were fabricated, which could act as a convenient and efficient Hg2+ test kits.
- Shi, Bingbing,Zhang, Peng,Wei, Taibao,Yao, Hong,Lin, Qi,Liu, Jun,Zhang, Youming
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p. 7981 - 7987
(2013/08/23)
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- Synthesis of some pyrido-imidazophenazine derivatives
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2,3-Diaminophenazine (1) was prepared1, 2, 3. Attempts were made to review the chemistry of phenazine8, biology of phenazine derivatives and also a review on fused phenazine derivatives; for studying their pharmacological15 and photoconductive properties17.
- El Bahnasawy,El Ahwany
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p. 1937 - 1944
(2008/02/10)
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- Metal complexes of a hexameric network tetrapyrazinoporpyrazine: I. Synthesis and identification
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Metal complexes of a hexameric network tetrapyrazineporpyrazine were synthesized by template polycyclotetramerization of pyrazine-2,3,5,6-tetracarboxamide in an urea melt in the presence of a corresponding metal acetate; irrespective of the metal, the polymerization degree of the polymeric ligand does not exceed six. A method for structural assessment of such compounds was proposed.
- Korzhenevskii,Markova,Efimova,Koifman,Krylova
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p. 980 - 984
(2007/10/03)
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