- Antibacterial and antitubercular activity of novel benzothiazole- aryl amine derivatives tethered through acetamide functionality
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A novel series of substituted benzothiazole-N-phenyl acetamides were synthesized through a feasible scheme and characterized by IR, 1H NMR and mass spectral methods. All the synthesized compounds were screened for antibacterial activity against two, Gram-positive strains: Staphylococcus aureus, Bacillus subtilis; four, Gram-negative strains: Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa and Klebsiella pneumonia; and antitubercular activity against mycobacterial strain: Mycobacterium tuberculosis. Among the 15 compounds (6a-o) tested, three compounds 6e, 6l and 6m have demonstrated high potency with MIC values ranges from 6.25-12.5 μg/mL against both Gram-positive and Gram-negative strains. Compounds 6e and 6l displayed remarkable antitubercular activity with MIC value of 25μg/mL.
- HAKIM, FARHANA,ROSHAN SALFIDOER
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p. 1757 - 1763
(2021/07/31)
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- CHEMICAL COMPOUNDS FOR THE INHIBITION OF UNDESIRED CELL PROLIFERATION AND USE THEREOF
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The present invention is related to compounds having the formula (I), wherein R1, R2, R3, R4, R5, X1, X2, T, U, V, W, Y and n are as defined in the claims, pharmaceutical compositions comprising the compounds and the use of the compounds for manufactur
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Page/Page column 58
(2010/02/13)
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