- BSA nanoparticles as controlled release carriers for isophethalaldoxime palladacycle complex; Synthesis, characterization,: In vitro evaluation, cytotoxicity and release kinetics analysis
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A new oxime ligand named isophthalaldoxime (1) was synthesized by the addition of hydroxylamine hydrochloride to isophthalaldehyde. Then, a four nuclear palladacycle complex {Pd4[(N,C)(NOHCHC6H2CHNOH)(μ-Cl)2]su
- Amirghofran, Zahra,Hajiaghasi, Afsaneh,Jamshidian, Nasrin,Karami, Kazem
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- Ferrocenyl bisoxazoline as an efficient non-phosphorus ligand for palladium-catalyzed copper-free Sonogashira reaction in aqueous solution
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Pd(OAc)2-catalyzed Sonogashira coupling reactions of alkynes and a variety of aryl halides with 1,3-bis(5-ferrocenylisoxazoline-3-yl)benzene as an efficient non-phosphorus ligand under copper-free conditions are presented. The main advantages over previous methodologies include low catalyst loading (0.2 mol% Pd(OAc)2 and 0.4 mol% ferrocenyl bisoxazoline ligand are sufficient for these coupling reactions), less problematic reaction medium (water–dimethylformamide) and more convenient operation (no requirement for nitrogen protection).
- Yu, Shuyan,Wu, Jingxin,He, Xinwei,Shang, Yongjia
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- Novel isoxazoline ligand with ferrocene backbone: Preparation and application in Heck reaction with water as solvent
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Two novel isoxazoline N,N-bidentate ligands with ferrocene backbone have been synthesized and employed for the palladium-catalyzed Heck coupling reaction. Among them, 1,3-bis-(5-ferrocenylisoxazoline-3-yl)benzene was found to be thermally stable and a highly effective ligand for Heck coupling reaction in neat water without N2 protection, affording the desired coupling products in good to excellent yield with high diastereoselectivity. The developed catalytic system was also well workable for 1,2-disubstituted alkenes, which were less involved in the Heck reaction for its larger steric hindrance. Copyright
- Yu, Shuyan,Zhang, Zhiqin,Yu, Zhiyu,Shang, Yongjia
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p. 657 - 660
(2014/08/05)
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- A versatile and green mechanochemical route for aldehyde-oxime conversions
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A robust, facile and solvent-free mechanochemical path for aldehyde-oxime transformations using hydroxylamine and NaOH is explored; the method is suitable for aromatic and aliphatic aldehydes decorated with a range of substituents. This journal is
- Aakeroey, Christer B.,Sinha, Abhijeet S.,Epa, Kanishka N.,Spartz, Christine L.,Desper, John
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supporting information
p. 11289 - 11291,3
(2012/12/12)
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- Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes
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Treatment of oximes with hypervalent iodine leads to substituted isoxazoles via rapid formation of nitrile oxides. Reaction with terminal alkynes led to a series of 3,5-disubstituted isoxazoles with complete regioselectivity and high yield, in a procedure
- Jawalekar, Anup M.,Reubsaet, Erik,Rutjes, Floris P. J. T.,Van Delft, Floris L.
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supporting information; experimental part
p. 3198 - 3200
(2011/05/05)
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- Carbohydrate-based spiro bis(isoxazolines): synthesis and evaluation in asymmetric catalysis
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Two carbohydrate-based spiro bis(isoxazolines) were synthesized via 1,3-dipolar cycloaddition from peracetylated methylene exo-glucal and the corresponding bis(arylnitrile oxide). The bis(cycloadducts) were then evaluated as ligands for enantioselective catalytic reactions. The Pd-catalyzed Tsuji-Trost reaction between a malonate and an allylic acetate did not provide good results. The poor conversion observed can be attributed to the rearrangement of the ligand in the reaction mixture to afford the corresponding ring-opened isoxazole which has been characterized. Both ligands were also evaluated in Cu(I)-catalyzed asymmetric imine alkynylation and afforded the product in good yield and modest enantioselectivity.
- Goyard, David,Telligmann, Susanne M.,Goux-Henry, Catherine,Boysen, Mike M.K.,Framery, Eric,Gueyrard, David,Vidal, Sébastien
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supporting information; experimental part
p. 374 - 377
(2010/03/24)
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- Synthesis of 1,3- and 1,4-bis(3-nitrofurazan-4-yl)benzenes and isomeric 1,3- and 1,4-bis[3(4)-nitrofuroxan-4(3)-yl]benzenes
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The 1,3- and 1,4-bis(3-nitrofurazan-4-yl)benzenes have been synthesized by dehydration of 1,3- and 1,4-bis(2-aminoglyoximo- 1-yl)benzenes followed by oxidation of amino groups. The 1,3- and 1,4-bis(3-nitrofuroxan-4-yl)benzenes have been prepared by nitroz
- Ovchinnikov, Igor V.,Finogenov, Alexey O.,Epishina, Margarita A.,Strelenko, Yuri A.,Makhova, Nina N.
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scheme or table
p. 217 - 219
(2009/12/05)
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- ZnO/CH3COCl: A new and highly efficient catalyst for dehydration of aldoximes into nitriles under solvent-free condition
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A rapid and efficient synthesis of nitriles via dehydration from the corresponding aldoximes has been carried out in the presence of ZnO/CH 3COCl as catalyst under solvent free conditions in 83-95% yields. The zinc oxide (ZnO) powder can be re-used upto three times after simple washing with CH2Cl2.
- Sarvari, Mona Hosseini
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p. 787 - 790
(2007/10/03)
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- Multiple Cycloadditive macrocyclization: An Efficient Method for Crown Ether-Type Cyclophanes, Bis-Calix[4]arenes and Silamacrocycles
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Macrocycles constitute a broad spectrum of compounds, which play a significant role in host-guest supramolecular chemistry. We have rationally designed an efficient novel synthetic method to synthesize different types of artificial receptive macrocycles containing isoxazoline or isoxazole ring systems. This method involves multiple (double, triple or quadrupole) cycloadditions between bifunctional dipoles and bifunctional dipolarophiles. We have presented our synthetic results to show the ease with which this one-pot synthetic method can be extended to synthesize different types of macrocycles such as cyclophanes, bis-calix[4]arenes and silamacrocycles. Hence, with appropriate combination of bifunctional dipoles and bifunctional dipolarophiles, the ring size of macrocycles could be controlled. This multiple cycloadditive macrocyclization will be a useful arsenal for the synthesis of various macrocycles.
- Kim, Byeang Hyean,Jeong, Eun Jeong,Hwang, Gil Tae,Venkatesan, Natarajan
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p. 2191 - 2202
(2007/10/03)
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- Mono et dinitrosation en position benzylique des complexes du benzene chrometricarbonyle. Synthese directe d'oximes et d'hydroximates
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In basic media, aromatic hydrocarbons and benzylmethylethers complexed by Cr(CO)3 units are readily nitrosated at the benzylic position by tBuONO, giving rise to Z and E oximes and hydroximates in moderate to excellent yields.With the meta-xylene and isochromane complexes it is possible to obtain a dinitrosation.
- Senechal-Tocquer, M.-C.,Senechal, D.,Bihan, J.-Y. Le,Gentric, D.,Caro, B.,et al.
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p. 261 - 278
(2007/10/02)
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