Minimizing the contribution of enterohepatic recirculation to clearance in rat for the NCINI class of inhibitors of HIV
A scaffold replacement approach was used to identifying the pyridine series of noncatalytic site integrase inhibitors. These molecules bind with higher affinity to a tetrameric form compared to a dimeric form of integrase. Optimization of the C6 and C4 po
Fader, Lee D.,Carson, Rebekah,Morin, Sébastien,Bilodeau, Fran?ois,Chabot, Catherine,Halmos, Ted,Bailey, Murray D.,Kawai, Stephen H.,Coulombe, René,Laplante, Steven,Mekhssian, Kevork,Jakalian, Araz,Garneau, Michel,Duan, Jianmin,Mason, Stephen W.,Simoneau, Bruno,Fenwick, Craig,Tsantrizos, Youla,Yoakim, Christiane
supporting information
p. 711 - 716
(2014/07/07)
INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
Compounds of formula I wherein a, R1, R2, R3, R4, R5 and R6 are defined herein, are useful as inhibitors of HIV replication.
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Page/Page column 45
(2010/12/01)
Studies on ketene and its derivatives. LIV. Reaction of diketene with ketene acetals
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Kato,Yamamoto,Takeda
p. 1047 - 1052
(2007/10/08)
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