- New fragmentation of 2-isoxazoline-5-carboxylic acid chlorides
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A novel base promoted degradation of 3-aryl-2-isoxazoline-5-carboxylic acid chlorides to aryl nitriles has been discovered.
- Golebiewski,Gucma
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p. 509 - 513
(2007/10/03)
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- Process for preparing aromatic nitriles
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Aromatic nitriles having the general formula (I): wherein: - Rrepresents the hydrogen atom., a fluorine, chlorine, bromine or iodine atom, a (C1-C5)-alkoxy group, a carboxy group, a (C1-C5)-carboxy-alkyl, or an aryl group selected from among phenyl, halo-phenyl, phenyl-ether or nitrile; - R' and R"either equal to, or different from, each other, represent the hydrogen atom or a fluorine, chlorine, bromine or iodine atom; are obtained by reacting an organic or inorganic ammonium salt (III):, , NH4(+) X(-) (III), , and an aromatic trichloromethyl derivative having formula (II): wherein R, R' and R" have the above set forth meaning, with the exception that when R in formula (I) represents the nitrile group, the corresponding R group in formula (II) represents the trichloromethyl group, operating in the presence of a catalyst consisting of a metal oxide or a metal salt. The process makes it possible high yields and high selectivities to the useful reaction product to be obtained.
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- Process for producing polychlorobenzonitrile
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A process for producing polychlorobenzonitrile having chlorine atoms at the 2,6-position by ammoxidation of toluene derivative having chlorine atoms at the 2,6-position with a gas containing ammonia and oxygen in vapor phase in the presence of a catalyst, characterized in that bromine and/or a bromine-containing compound is added to the reaction system.
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- Process for producing 2,6-difluorobenzonitrile
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A process for producing 2,6-difluorobenzonitrile comprises reducing a chloro fluorobenzonitrile selected from 3-chloro-2,6-difluorobenzonitrile, 3,5-dichloro-2,6-difluorobenzonitrile or a mixture thereof by hydrogen gas in the presence of a palladium or platinum catalyst at a temperature of 0° to 200° C.
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