- Efficient dimerization of formic acid in aqueous solution induced by Ar-Arc plasma
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Introduction of argon-arc plasma into an aqueous solution of formic acid resulted in the formation of oxalic acid. The reaction conditions for the dimerization were studied. The maximum yield of oxalic acid reached 47-50% when the reaction was carried out using sodium formate or calcium formate. Dimerization of acetic acid was also examined.
- Harada, Kaoru,Ito, Yoshimi,Wada, Toshinori,Munegumi, Toratane
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- DECOMPOSITION PRODUCTS OF HALONITROACETIC ACID DERIVATIVES
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The halonitro group O2NCHX of chloro- and bromonitroacetic acid derivatives underwent reduction to H2NCO upon boiling.The same derivatives decomposed to oxalic acid upon long storage.Likely chemical transformation pathways are discussed. Keywords: chloro- and bromonitroacetic acids, reduction, oxalic acid, amides.
- Yurtanov, A. I.
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Read Online
- Preparation method of oxamide
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The invention provides a preparation method of oxamide. The preparation method comprises the following steps: an intermediate oxamide derivative is prepared from CO, O2 and amine compounds as raw materials by oxidation and carbonylation under the action of a catalyst 1, and then, oxamide is prepared through aminolysis of the oxamide derivative under the action of a catalyst 2. A novel method is used for coproducing oxamide and the oxamide derivative, and the problems that oxalate synthesis materials are poisonous, catalyst efficiency is low and the like in the original technology for synthesizing oxamide through aminolysis of oxalate are solved. Besides, the technologically synthesized oxamide derivative has good substrate applicability and can be applied to fields of medicine, pesticides,synthetic ligands, food additives and the like.
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Paragraph 0074-0081; 0090
(2019/08/03)
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- Process method of co-production of oxamide and carbamic acid ester through ammonia ester exchange method
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The invention discloses a process method of co-production of oxamide and carbamic acid ester through an ammonia ester exchange method. According to the process method, urea and oxalic acid diethyl serve as raw materials, and two products, namely the oxamide and the carbamic acid ester, can be obtained at the same time through a series of ammonia ester exchange reactions. By means of the process, the problems that products are singular, and by-products affect the reaction process in an original technology for synthesizing oxamide through oxalic acid diethyl ammonolysis and a technology for synthesizing carbamic acid ester through urea alcoholysis are solved; besides, due to the fact that urea is obtained through CO and NH synthesis, NH is replaced with urea, and the process method has active significance in converting CO into high added-value chemicals and efficiently utilizing CO.
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Paragraph 0048; 0049
(2016/10/08)
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- Chemical evolution of simple amino acids to asparagine under discharge onto the primitive hydrosphere: Simulation experiments using contact glow discharge
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Asparagine is an important amino acid for abiotic polypeptide synthesis. In simulation experiments, it was obtained in 3.0% yield (based on the amount of consumed alanine) from alanine (100 mM) and formamide (200 mM) by contact glow discharge (Harada discharge) onto aqueous solutions. The present results suggest that asparagine could be abiotically synthesized from simple amino acids under possible primitive earth conditions.
- Munegumi, Toratane
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p. 1208 - 1215
(2015/02/19)
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- Transformation of thioamide compounds to corresponding amides using 12-Tungstosilicic acid
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12-Tungstosilicic acid (H4SiW12O40) is applied for the conversion of a series of thioamides to their corresponding oxo analogues in excellent yields in acetonitrile. In the case of thioketones, no reaction is observed under these conditions. The reusability of the catalyst also is investigated.
- Nasr-Esfahani, Masoud,Montazerozohori, Morteza,Moghadam, Majid,Mohammadpoor-Baltork, Iraj,Moradi, Sareh
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experimental part
p. 261 - 266
(2010/06/19)
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- Acidified, wet, silica-supported tetrabutylammonium periodate: A convenient and mild reagent for conversion of thioamides to their corresponding amides under solvent-free conditions
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A series of thioamides are transformed to their corresponding oxo analogues in good to excellent yields with acidified, wet, silica-supported tetrabutylammonium periodate under solvent-free conditions.
- Nasr-Esfahani, Masoud,Moghadam, Majid,Mohammadpoor-Baltork, Iraj,Boostanifar, Mohammad Hasan
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experimental part
p. 2004 - 2009
(2010/01/17)
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- A mild and convenient method for conversion of thioamides to their corresponding amides using acidified wet silica-supported permanganate under solvent-free conditions
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A mild and efficient method for conversion of thioamides to their corresponding amides is reported. A series of thioamides are transformed to their corresponding carbonyl compounds in good to excellent yields by acidified wet silica-supported permanganate under solid phase conditions.
- Nasr-Esfahani, Masoud,Moghadam, Majid,Mohammadpoor-Baltork, Iraj,Boostanifar, Mohammad Hasan
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experimental part
p. 141 - 146
(2009/04/10)
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- Facile desulfurization of thioamides and thioureas with tetrabutylammonium periodate under mild conditions
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Thioamides and thioureas were reacted with tetrabutylammonium periodate at room temperature to afford the corresponding amides and ureas, respectively, under aprotic conditions. Springer-Verlag 2005.
- Pourali, Ali Reza
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p. 733 - 737
(2007/10/03)
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- Inhibitors of the ICE/ced-3 family of cysteine proteases
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This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, R, R1, R1′ p and q are as defined herein. The invention is also directed to pharmaceutical compositions containing one or more of these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmnune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
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- Selective oxidative carbonylation of amines to oxamides and ureas catalyzed by palladium complexes
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A new process for converting secondary amines into N,N,N′,N′- tetraalkyloxamides under CO pressure, catalyzed by homogeneous palladium complexes in the presence of 1,4-dichloro-2-butene (DCB) as an oxidant, has been developed. The mechanism of the oxidative double-carbonylation process, consisting of the oxidation of Pd(0) to Pd(11) with DCB through a β-chloride elimination of the η3-(chloromethyl) allylpalladiuni(11) intermediate, the formation of mono- and bis(carbamoyl)palladium species, and a reductive elimination of the two carbamoyl ligands, is proposed based on studies of the behavior of carbamoylpalladium complexes. When primary amines are employed with DCB as the oxidant, N,N′-dialkyloxamide is catalytically produced, whereas urea is exclusively produced when iodine is used as the oxidant. The reaction of an N-monopropylcarbamoylpalladium complex with propylamine under CO gave N,N′-dipropylurea, whereas a treatment with diethylamine yielded unsymmetrical N,N-diethyl-N′-propylurea, implying the intermediate formation of propyl isocyanate that is converted into the urea upon a reaction with the added amine. A kinetic study on the reaction of chloro-N- propylcarbamoylpalladium with triethylamine suggested a process proceeding through a base-promoted dcprolonalion of the N-monoalkylcarbamoyl ligand to form propyl isocyanate.
- Hiwatari, Kozo,Kayaki, Yoshihito,Okita, Koshi,Ukai, Tomohiro,Shimizu, Isao,Yamamoto, Akio
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p. 2237 - 2250
(2007/10/03)
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- A new class of near-infrared electrochromic oxamide-based dinuclear ruthenium complexes
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(Chemical equation presented) We report the synthesis of a new class of symmetric and unsymmetric oxamide-based dinuclear ruthenium complexes. These complexes were characterized by NMR, ESI-MS, and electrochemical methods. Spectroelectrochemical analysis of the complexes showed broad absorptions in the NIR region for the mixed-valence state of the complexes. The introduction of a chiral group into the bridging ligand produced an optically active complex that was studied using circular dichroism.
- Rastegar, Majid F.,Todd, Erin K.,Tang, Hongding,Wang, Zhi Yuan
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p. 4519 - 4522
(2007/10/03)
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- Bismuth(III) nitrate pentahydrate: A convenient and selective reagent for conversion of thiocarbonyls to their carbonyl compounds
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A variety of thioamides and thioureas are rapidly transformed to their oxo derivatives with Bi(NO3)3·5H2O in excellent yields. However, thiono esters and thioketones are converted to their corresponding carbonyl compounds in only poor yields. Bi(NO3)3·5H2O is relatively non-toxic, insensitive to air and inexpensive. These features coupled with the selective deprotection of thioamides and thioureas in the presence of thiono esters and thioketones make this method an attractive alternative to the existing routes for deprotection of thiocarbonyl compounds.
- Mohammadpoor-Baltork, Iraj,Khodaei, Mohammad Mehdi,Nikoofar, Kobra
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p. 591 - 594
(2007/10/03)
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- A facile and convenient method for deprotection of thiocarbonyls to their carbonyl compounds using oxone under aprotic and nonaqueous conditions
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The reaction of oxone as an inexpensive, stable, and commercially available reagent with thiocarbonyl compounds in refluxing acetonitrile has been studied. Primary, secondary, and tertiary thioamides and thioureas are converted to their oxo analogues efficiently. Thiono esters also are transformed to their corresponding esters, while thioketones remained intact under these conditions.
- Mohammadpoor-Baltork,Sadeghi,Esmayilpour
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- Selective conversion of thioamides and thioureas to their oxygen analogues using quinolinium fluorochromate
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The synthetic utility of quinolinium fluorochromate (QFC) in deprotection of thiocarbonyl compounds is reported. A variety of primary and secondary thioamides and thioureas are converted to their oxo derivatives in high yields. However, tertiary thioamides afford their amides in relatively poor yields. Selective deprotection of thioamides and thioureas in the presence of thionoesters and thioketones is noteworthy advantage of this method.
- Tajbakhsh,Mohammadpoor-Baltork,Alimohammadi
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p. 2638 - 2640
(2007/10/03)
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- A convenient and inexpensive method for conversion of thiocarbonyl compounds to their oxo derivatives using oxone under solvent-free conditions
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A series of thioamides, thioureas and thioesters are transformed to their corresponding carbonyl compounds in good to excellent yields with oxone under solid phase conditions, while thioketones remained unchanged under these conditions.
- Mohammadpoor-Baltork, Iraj,Sadeghi, Majid M.,Esmayilpour, Karim
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p. 953 - 959
(2007/10/03)
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- Convenient transformation of thiocarbonyl to carbonyl group using benzyltriphenylphosphonium and n-butyltriphenylphosphonium peroxodisulfates
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Benzyltriphenylphosphonium and n-butyltriphenylphosphonium peroxodisulfates are stable and easily prepared oxidising agents. These reagents are able to convert different thioamides and thioureas to their oxygen analogues in good to excellent yields. Thiono esters are also transformed to esters in high yields. Thioketones such as thiobenzophenone and thiofluorenone are converted to their ketones in high yields while, 4-nitrothiobenzophenone, 2-aminothiobenzophenone and 4-chlorothiobenzophenone remained intact in the reaction mixture.
- Mohammadpoor-Baltork, Iraj,Sadeghi, Majid M. M.,Esmayilpour, Karim
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p. 348 - 350
(2007/10/03)
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- Novel non-convalent thrombin inhibitors
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The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and an optionally substituted heteroaryl group at P1. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.
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- Inhibitors of the ICE/ced-3 family of cysteine proteases
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This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, R, R1, R1′ p and q are as defined herein. The invention is also directed to pharmaceutical compositions containing one or more of these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmnune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
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- Process for producing oxamide
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Oxamide is produced in a high purity by a process comprising (A) melting a starting material comprising 70 to 100 wt % of an oxalic acid diester of an aliphatic alcohol and 0 to 30 wt % of the same aliphatic alcohol as mentioned above, (B) feed-mixing an ammonia-containing gas to the starting material melt, while stirring, to produce oxamide and the aliphatic alcohol (by-product), (C) continuing the ammonia-feed-mixing procedure while controlling a feed rate of ammonia to an extent such that a content of the aliphatic alcohol in the reaction mixture is maintained at a level of 3 to 45% by weight, to produce a wetted solid reaction product comprising the resultant oxamide and the aliphatic alcohol, and then (D) collecting the oxamide from the reaction product by evaporating away the aliphatic alcohol.
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Page column 5 - 6, 7 - 8
(2008/06/13)
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- Use of oxamate derivatives as depigmenting agents
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The invention relates to the use of oxamate derivatives in a composition, as agents for depigmenting and/or bleaching human skin, head hair and/or other hairs. The invention also relates to a process for depigmenting and/or bleaching the skin, head hair and/or other hairs, which includes applying a composition comprising oxamate derivatives to human skin, head hair and/or other hairs.
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- Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
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Substituted 2-acylaminopyridine compounds and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders.
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- PHENYLALKYL OXAMIDES
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Novel oxamide derivatives are described which inhibit the production of TNF and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful as inhibitors of PDE IV and are therefor useful in the treatment of disease states mediated or exacerbated thereby
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- Novel syntheses of oxamides, oxamates and oxalates from diisopropenyl oxalate
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Diisopropenyl oxalate, obtained by catalytic addition of oxalic acid to propyne, is a useful reagent for the access to a variety of α-dicarbonyl compounds such as oxamides, oxamates and oxalates, under very mild conditions.
- Neveux, Muriel,Bruneau, Christian,Lecolier, Serge,Dixneuf, Pierre H.
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p. 2629 - 2640
(2007/10/02)
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- Preparations of carboxylic acid esters containing heptafluoroisopropyl groups
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The reaction of fluoroglyoxylic acid esters and fluoroformic acid esters with perfluoropropene (PFP) yielded perfluoro(3-methyl-2-oxobutyric) acid esters and perfluoroisobutyric acid esters, respectively.Oxamide derivatives and 2,3-quinoxalinediol have been prepared by the reaction of perfluoro(3-methyl-2-oxobutyric) acid esters with amines and o-phenylenediamine, respectively.Perfluoro(3-methyl-2-oxobutyric) acid esters give perfluoroisobutyric acid esters on heating in the presence of fluoride ion in an aprotic solvent.
- Suyama, T.,Kato, S.,Mizutani, Y.
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- Method of purification of the oxalic acid diamide
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A method of removing copper from oxamide obtained through a process which involves the use of copper catalysts, by contacting it with an aqueous solution of a suitable complexing agent, which is capable of forming copper-containing water-soluble complexes and imparts to the aqueous solution a pH comprised between 2 and 8, optionally repeating the contacting step and, finally, recovering the purified oxamide by solid-liquid separation techniques. The claimed process affords oxamide containing less than 25 ppm of copper.
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- 3-aminoalkyl-1H-indole-5-urea and amide derivatives
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Compounds useful as antihypertensive agents which are 3-aminoalkyl-1H-indole-5-urea or amide derivatives having the following formula: STR1 or a pharmaceutically acceptable acid addition salts thereof, wherein: R is C 1-4 loweralkyl, C 1-4 loweralkoxy, phenyl, STR2 pyrrolyl, pyridyl or is a substituted nitrogen represented by: STR3 wherein R 1 is H or a C 1-4 loweralkyl or phenyl or cycloalkyl; R 2 is H or a C 1-4 loweralkyl; Y is H or halo; R 3 is H or a C 1-4 loweralkyl; R 4 is H or a C 1-4 loweralkyl; R 5 is H or a C 1-4 loweralkyl or carboxymethyl or carboxytrifluoromethyl; R 6 is H or a C 1-4 loweralkyl, and R 5 and R 6 may also be taken together as an N-loweralkyl-pyrrolidinylidene group.
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- Process for preparing 1,2,4-triazole-3-carboxamides
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There is disclosed a process for preparing a 1,2,4-triazole-3-carboxamide represented by the formula: STR1 wherein, R1 and R2 represent independently a hydrogen atom, an alkyl group, a cycloalkyl group or an aryl group, or both R1 and R2 represent an alkylene group linked with each other directly or through an oxygen atom or a nitrogen atom to form a ring together with the nitrogen atom to which they are attached, which comprises subjecting an oxamohydrazide represented by the formula: STR2 wherein R1 and R2 have the same meanings as defined above, to reaction with formamidine or a salt thereof.
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- Heterogeneous Catalytic Hydration of α-Hydroxynitriles
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In the hydration of α-hydroxyisobutironitrile and α-hydroxy-α-methylbutyronitrilr in the presence of manganese(IV) oxide we have detected an initial side-reaction: dehydrocyanation of the α-hydroxynitrile and adsorption of most of the resulting hydrocyanic acid on the catalyst surface, followed by addition of water to the unchanged α-hydroxynitrile with formation of an amide.The quantitative dependence of the yield of amide on the initial concentration of α-hydroxynitrile in the reaction mixture and the equilibrium constant of the dehydrocyanation have been calculated.
- Zil'berman, E. N.,Eremeev, I. V.
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p. 471 - 472
(2007/10/02)
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- BICYCLIC PEROXIDES FROM A 1,4-DIAZEPINE
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An adduct, 3,4-dicyano-1,6-dimethyl-2,5-diaza-7,8-dioxabicyclonon-3-ene, was obtained from 2,3-dicyano-5,7-dimethyl-6H-1,4-diazepine and hydrogen peroxide in the presence of alkali or a tertiary amine.It was dehydrogenated by iodobenzene diacetate into 3,4-dicyano-1,6-dimethyl-2,5-diaza-7,8-dioxabicyclonona-2,4-diene; further oxidation by m-chloroperbenzoic acid gave 4,5-dicyano-1,8-dimethyl-2,7-diaza-3,6,9,10-tetraoxatetracyclo2,405,7>undecane.
- Ramakrishnan, V. T.,Boyer, Joseph H.
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p. 1345 - 1351
(2007/10/02)
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- Novel acyloxamides and plant growth regulant compositions
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Acyloxamide compounds of the formula STR1 in which R is chlorine, alkyl of from 1 or 2 carbon atoms or chloroalkyl of from 1 or 2 carbon atoms and 1 to 5 chlorine atoms e.g., 2,2-dichloropropionyl-oxamide and trichloroacetyl-oxamide are outstandingly effective as plant growth regulants. sp This is a continuation of application Ser. No. 964,223 filed Nov. 27, 1978, abandoned.
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- Process for preparing acid amides
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The acid amides are produced by a process comprising hydrating a nitrile compound in the presence of a copper-containing polymer having basic nitrogenous groups in the polymer chain or linked with the polymer chain as a catalyst.
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- Process for the preparation of oxamide
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By contacting hydrogen cyanide with oxygen or air and a catalyst solution containing water, low molecular weight aliphatic carboxylic acids, copper ions and nitrate ions oxalic acid diamide is formed in high yields.
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