- Switching the adhesive state of catecholic hydrogels using phototitration
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A polyacrylamide hydrogel system that can be liquefied by remote activation using UV irradiation is investigated as a degradable adhesive. The linear polyacrylamide copolymer, formed by conventional free-radical polymerization, contains biomimetic catechol-iron-mediated cross-linkers that are sensitive to pH changes. Hydrogel films and bulk gels are prepared by basic titration of a polymer solution doped with a photoacid generator, diphenyliodonium chloride, generating an ionic cross-linked network via the catechol pendant groups. Irradiation of these hydrogels with UV light affords a viscous liquid solution, demonstrating a gel-sol transition with a subsequent decrease in the adhesive strength of the material. These gels may be prepared in high throughput and require few synthetic steps with commercially available precursors.
- White, Evan M.,Seppala, Jonathan E.,Rushworth, Parker M.,Ritchie, Branson W.,Sharma, Suraj,Locklin, Jason
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- On-demand and negative-thermo-swelling tissue adhesive based on highly branched ambivalent PEG-catechol copolymers
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A series of well-designed highly branched PEG-catechol based thermo-responsive copolymers were synthesized via a one-pot RAFT polymerization. A varying degree of photocrosslinkable (meth)acrylate moieties were incorporated within the 3D structure to allow
- Zhang, Hong,Zhao, Tianyu,Newland, Ben,Duffy, Patrick,Annaidh, Aisling N,O'Cearbhaill, Eoin D.,Wang, Wenxin
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- Stimuli-Responsive Supramolecular Hydrogels with High Extensibility and Fast Self-Healing via Precoordinated Mussel-Inspired Chemistry
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Supramolecular hydrogels have the advantages of stimuli responsiveness and self-healing compared to covalently cross-linked hydrogels. However, the existing supramolecular hydrogels are usually poor in mechanical properties, especially in extensibility. I
- Hou, Sen,Ma, Peter X.
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- Bio-inspired smart hydrogel with temperature-dependent properties and enhanced cell attachment
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Stimuli-responsive smart hydrogels have been exploited for various applications, including as biomaterials with environment-dependent changes in hydrophobicity, stiffness or volume. In this study, we report the functionalisation of a temperature-responsiv
- Kim, Young-Jin,Tachibana, Misa,Umezu, Mitsuo,Matsunaga, Yukiko T.
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- Electrospun composite nanofibrous membrane as wound dressing with good adhesion
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A photopolymerizationable mimic mussel protein structure monomer, dopamine methacrylamide (DMA), was synthesized. The photopolymerization of DMA was analysed by series real time near infrared spectroscopy (SRTIR). Dopamine methacrylamide/poly (ethylene ox
- Niu, Rui,Qiao, Jing,Yu, Hang,Nie, Jun,Yang, Dongzhi
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- Robust platforms for creating organic-inorganic nanocomposite microspheres: Decorating polymer microspheres containing mussel-inspired adhesion layers with inorganic nanoparticles
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We describe a method for creating robust and stable core-shell polymer microspheres decorated with inorganic (IO) nanoparticles (NPs) by a self-organization process and heterocoagulation using a mussel-inspired polymer adhesive layer between the IO NPs an
- Satoh,Saito,Yabu
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- Biomimetic adhesive materials containing cyanoacryl group for medical application
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For underwater adhesives with biocompatible and more flexible bonds using biomimetic adhesive groups, DOPA-like adhesive molecules were modified with cyanoacrylates to obtain different repeating units and chain length copolymers. The goal of this work is
- Jo, Sueng Hwan,Sohn, Jeong Sun
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- Nitrocatecholic copolymers-synthesis and their remarkable binding affinity
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Nitrocatecholic random copolymers were obtained from nitration of protected catechol-N-isopropylacrylamide copolymers. Incorporation of 5% nitrocatecholic counits can lead to remarkable enhancement of the binding affinity toward Fe3O4/sub
- Qiu, Shenjie,Zhuang, Jianqin,Jin, Shi,Yang, Nan-Loh
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- Bioinspired Surface Functionalization of Titanium for Enhanced Lubrication and Sustained Drug Release
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Titanium and its alloys have long been used as implantable biomaterials in orthopedics; however, to the best of our knowledge, few studies were reported to investigate surface functionalization of titanium for enhanced lubrication and sustained drug relea
- Han, Ying,Liu, Sizhe,Sun, Yulong,Gu, Yanhong,Zhang, Hongyu
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- SPIONs/DOX loaded polymer nanoparticles for MRI detection and efficient cell targeting drug delivery
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In this research, reducible polydopamine coated magnetic nanoparticles (SPIONs@PDA) were prepared and doxorubicin (DOX) was encapsulated for both magnetic resonance imaging (MRI) detection and cell targeting drug delivery. The SPIONs@PDA exhibited excelle
- Shang, Le,Wang, Qiu-Yue,Chen, Kang-Long,Qu, Jing,Zhou, Qing-Han,Luo, Jian-Bin,Lin, Juan
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- SYSTEMS AND METHODS FOR N-HALAMINE-DOPAMINE COPOLYMERS FOR HIGH-PERFORMANCE, LOW-COST, AND EASY-TO-APPLY ANTIMICROBIAL COATINGS
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The present application relates to copolymers of N-halamine (HA) and dopamine (DMA) and their method of formation. The HA and DMA are present in the copolymer in a ratio of 0.4:9.6 to 9.6:0.4 (HA: DMA). The copolymers can be used in novel antimicrobial co
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Paragraph 0098
(2020/01/11)
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- Activated dopamine derivatives as primers for adhesive-patch fixation of bone fractures
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For the stabilization of complex bone fractures, tissue adhesives are an attractive alternative to conventional implants, often consisting of metal plates and screws whose fixation may impose additional trauma on the already fractured bone. This study reports on the synthesis and evaluation of activated dopamine derivatives as primers for fiber-reinforced-adhesive patches in bone-fracture stabilization strategies. The performance of synthesized dopamine derivatives are evaluated with regard to the adhesive shear strength of formed bone patches, as well as cell viability and surface properties. Dopamine-derived primers with methacrylamide, allyl, and thiol functional groups were found to significantly increase the adhesive shear strength of adhesive patches. Furthermore, deprotonation of the primer solution was determined to be essential in order to achieve good adhesion. In conclusion, the primer solutions that were found to give the best adhesion were the once where dopa-thiol was used in combination with either dopa-methacrylamide or dopa-allyl, resulting in shear bond strengths of 0.29 MPa.
- Olofsson,Granskog,Cai,Hult,Malkoch
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p. 26398 - 26405
(2016/03/25)
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