- 7-(Piperazine-1-Ymethyl)-1H-Indole-2-Carboxylic Acid (Phenyl)-Amide Derivatives and Allied Compounds as P38 Map Kinase Inhibitors for the Treatment of Respiratory Diseases
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The present invention provides compounds according to general formula (I) which are proposed for the treatment of respiratory complaints, particularly asthma and COPD.
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Page/Page column 55
(2011/11/12)
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- Discovery and optimization of p38 inhibitors via computer-assisted drug design
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Integration of computational methods, X-ray crystallography, and structure-activity relationships will be disclosed, which lead to a new class of p38 inhibitors that bind to p38 MAP kinase in a Phe out conformation.
- Goldberg, Daniel R.,Hao, Ming-Hong,Qian, Kevin C.,Swinamer, Alan D.,Gao, Donghong A.,Xiong, Zhaoming,Sarko, Chris,Berry, Angela,Lord, John,Magolda, Ronald L.,Fadra, Tazmeen,Kroe, Rachel R.,Kukulka, Alison,Madwed, Jeffrey B.,Martin, Leslie,Pargellis, Christopher,Skow, Donna,Song, Jinhua J.,Tan, Zhulin,Torcellini, Carol A.,Zimmitti, Clare S.,Yee, Nathan K.,Moss, Neil
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p. 4016 - 4026
(2008/02/12)
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- Bis-Amination of Aryl Halides
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Disclosed are methods for making 1,3- and 1,4-diamino-phenyl intermediates by utilizing bis-amination of ortho-substituted aryl halides.
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Page/Page column 4
(2008/06/13)
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- 1,4-Disubstituted benzo-fused compounds
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Disclosed are novel 1,4-disubstituted benzo-fused compounds wherein G, X, L, Q, n and Y are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic infla
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