cas 474-74-8, N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine

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Supramolecular Gels from Conjugates of Bile Acids and Amino Acids and Their Applications
Hydrogels composed of low molecular weight molecules are gaining increasing importance in biomedical applications. In this work, we report the formation of injectable hydrogels from bile acid–amino acid conjugates. The hydrogelation ability was dependent
Maity, Mitasree,Maitra, Uday
p. 1713 - 1720
(2017/04/13)

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor
The Eph receptor-ephrin system is an emerging target for the development of novel antiangiogenetic agents. We recently identified lithocholic acid (LCA) as a small molecule able to block EphA2-dependent signals in cancer cells, suggesting that its (5β)-cholan-24-oic acid scaffold can be used as a template to design a new generation of improved EphA2 antagonists. Here, we report the design and synthesis of an extended set of LCA derivatives obtained by conjugation of its carboxyl group with different α-amino acids. Structure-activity relationships indicate that the presence of a lipophilic amino acid side chain is fundamental to achieve good potencies. The l-Trp derivative (20, PCM126) was the most potent antagonist of the series disrupting EphA2-ephrinA1 interaction and blocking EphA2 phosphorylation in prostate cancer cells at low μM concentrations, thus being significantly more potent than LCA. Compound 20 is among the most potent small-molecule antagonists of the EphA2 receptor.
Incerti, Matteo,Tognolini, Massimiliano,Russo, Simonetta,Pala, Daniele,Giorgio, Carmine,Hassan-Mohamed, Iftiin,Noberini, Roberta,Pasquale, Elena B.,Vicini, Paola,Piersanti, Silvia,Rivara, Silvia,Barocelli, Elisabetta,Mor, Marco,Lodola, Alessio
p. 2936 - 2947
(2013/05/22)

Lithocholic acid analogues, new and potent α-2,3-sialyltransferase inhibitors
A new type of noncompetitive α-2,3-sialyltransferase inhibitor has been synthesized; we report the discovery, preparation and inhibitory activity of sixteen lithocholic acid analogues. The Royal Society of Chemistry 2006.
Chang, Kai-Hsuan,Lee, Lenselot,Chen, Jessica,Li, Wen-Shan
p. 629 - 631
(2008/02/10)

An improved procedure for the synthesis of glycine and taurine conjugates of bile acids
Glycine and taurine conjugates of 5β cholanic acids have been synthesized using improved procedures based on the peptide coupling reagent, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. The conjugates are obtained in chromatographically pure form in yields higher than 90%. The use of this procedure in the large scale preparation of choly[1,2 13C2]glycine is described.
Tserng,Hachey,Klein
p. 404 - 407
(2007/10/06)

Chemical Properties

Melting Point: 212-214 °C
Boiling Point: 619.7°Cat760mmHg
Flash Point:328.6°C
Density: 1.112g/cm³
Solubility:Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
Storage Temp.:Refrigerator
Refractive Index: 1.6000 (estimate)
PKA: 3.58±0.10(Predicted)
PSA: 86.63000
LogP: 5.01420

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474-74-8

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Chemical Properties

Melting Point: 212-214 °C

Boiling Point: 619.7°Cat760mmHg

Flash Point:328.6°C

Density: 1.112g/cm³

Solubility:Chloroform (Slightly, Heated), Methanol (Slightly, Heated)

Storage Temp.:Refrigerator

Refractive Index: 1.6000 (estimate)

PKA: 3.58±0.10(Predicted)

PSA: 86.63000

LogP: 5.01420

Global suppliers and manufacturers of 474-74-8total 19 suppliers on LookChem

Article Database

474-74-8

Articles about 474-74-8Total 4 be found

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Chemical Properties

Melting Point: 212-214 °C

Boiling Point: 619.7°Cat760mmHg

Flash Point:328.6°C

Density: 1.112g/cm3

Solubility:Chloroform (Slightly, Heated), Methanol (Slightly, Heated)

Storage Temp.:Refrigerator

Refractive Index: 1.6000 (estimate)

PKA: 3.58±0.10(Predicted)

PSA: 86.63000

LogP: 5.01420

Global suppliers and manufacturers of 474-74-8total 19 suppliers on LookChem

Density: 1.112g/cm³