Novel benzimidazole derivatives as selective CB2 agonists
The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1 nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to excellent selectivity (>1000-fold) over the CB1 receptor.
BENZIMIDAZOLES AND IMIDAZOPYRIDINES USEFUL IN THE TREATMENT OF DISEASES OR DISORDERS ASSOCIATED WITH CANNABINOID RECEPTOR 2 (CB2) SUCH AS PAIN
This invention relates to novel benzimidazoles and imidazopyridines having the structural of formula I below and their pharmaceutically acceptable salts, tautomers or in vivo -hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide treatments of CB2 associated disorders.
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Page/Page column 50; 77
(2008/06/13)
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