cas 475-67-2, ISOCORYDINE HYDROCHLORIDE | Articles data ｜lookchem

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475-67-2

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ALKALOIDS OF Glaucium fimbrilligerum
From the epigeal part and roots of Glaucium fimbrilligerum 22 alkaloids have been isolated, of which three have proved to be new - d-isocorytuberine, dehydrocorydine, and coridine N-oxide.
Karimova, S. U.,Israilov, I. A.,Yunusov, M. S.,Yunusov, S. Yu.
p. 177 - 180
(1980)
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Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine
Many compound collections used in high-throughput screening are composed of members whose structural complexity is considerably lower than that of natural products. We previously reported a strategy for the synthesis of complex and diverse small molecules from natural products using ring-distortion reactions, called complexity-to-diversity (CtD), and herein, CtD is applied in the synthesis of 16 diverse scaffolds and 65 total compounds from the alkaloid natural product sinomenine. Chemoinformatic analysis shows that these compounds possess complex ring systems and marked three-dimensionality.
Garcia, Alfredo,Drown, Bryon S.,Hergenrother, Paul J.
p. 4852 - 4855
(2016/10/18)

Asymmetric total synthesis of (S)-isocorydine
The asymmetric total synthesis of (S)-isocorydine, a potential drug for the cure of hepatocellular carcinoma, is described. Asymmetric transfer hydrogenation of 3,4-dihydroisoquinoline using a chiral Ru(II) catalyst was applied to the synthesis of isocory
Zhong, Mei,Jiang, Yunbin,Chen, Yali,Yan, Qian,Liu, Junxi,Di, Duolong
p. 1145 - 1149
(2015/10/28)

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Chemical Properties

Melting Point: 216-220 °C(lit.)
Boiling Point: 506.1°Cat760mmHg
Flash Point:259.9°C
Density: 1.222g/cm³
Vapor Pressure: 7.29E-11mmHg at 25°C
Refractive Index: 1.5614 (estimate)
PKA: 9.41±0.20(Predicted)
PSA: 51.16000
LogP: 3.10800

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