The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negativ
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Page/Page column 37-39
(2017/01/05)
β-lactones as privileged structures for the active-site labeling of versatile bacterial enzyme classes
(Chemical Equation Presented) A chemical proteomic strategy has been applied directly to bacterial proteomes, and b-lactones have been identified as important natural product derivatives with a high affinity to various enzyme classes (see picture). This a
Boettcher, Thomas,Sieber, Stephan A.
supporting information; experimental part
p. 4600 - 4603
(2009/02/08)
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