- New Reagents for the Regiospecific Synthesis of Naturally Occurring Quinizarins
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A modified Nef reaction applied to 4-nitrobutanoates gives the corresponding acetals which after hydrolysis and enol silylation yield the new 1,3-dienes 1-methoxy-1,4-bis(trimethylsiloxy)butadiene and its 3-methyl derivative.The latter reacts smoothly with chloronaphthoquinones and provides simple and efficient syntheses of 2-methylquinizarin, islandicin, digitopurpone, and erythroglaucin.
- Simoneau, Bruno,Savard, Jacques,Brassard, Paul
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p. 5433 - 5434
(2007/10/02)
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