- Method for synthesizing simvastatin impurity D
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The invention provides a method for synthesizing a simvastatin impurity D. The method comprises the following steps: by taking easily available raw material medicine simvastatin as an initial raw material, firstly carrying out ring opening on lactone, then protecting two hydroxyl groups in a molecule by using acetonylidene, and condensing an obtained intermediate with another molecule raw material medicine simvastatin, and finally, removing the protecting group acetone by using hydrochloric acid to obtain the simvastatin impurity D. According to the method, the simvastatin which is cheap and easy to obtain is taken as a starting raw material, a final target product is obtained through four-step reaction, the whole reaction route is simple and economical, and has very high practical value, and a relatively large amount of preparation can be carried out for guiding production; meanwhile, the blank of no report about the synthesis method of the compound up to now is filled.
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Paragraph 0048-0050; 0054
(2021/05/08)
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- Process for lactonization to produce simvastatin
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There is disclosed a process for the manufacture of simvastatin of Formula I which comprises heating a compound, namely acid or ammonium salt of compound of Formula II, where Z is H or NH4 in an organic solvent at a temperature of 130-140° C. NameResidenceCitizenshipRamesh403, Janapriya Pramila EnclaveIndiaDandalaUma Nagar, Kundanbagh, BegumpetHyderabad - 500 016 (India)Sonny505, Vishal Towers, A BlockIndiaSebastianA.S. Raju Nagar, Kukatpally,Hyderabad - 500 072 (India)Sanapureddy4/134, Pakeerpalli,IndiaJagan MohanSankarapuram (post)ReddyCuddapah - 516 002 (India)MeenakshisunderamD-1, Hidden Treasure ApartmentsIndiaSivakumaranNear Ayyappa Swami Temple LaneSomajiguda, Hyderabad - 500 082(India)
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