- 4'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF EBOLA VIRUS RNA REPLICATION
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The application discloses compounds of Formula I wherein the variable substituents are as defined herein. The compounds of Formula I and pharmaceutical compositions comprising compounds of Formula I are useful for the treatment of diseases mediated by Filoviruses such as Ebolavirus.
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Paragraph 0329
(2016/09/12)
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- Azido nucleosides and nucleotide analogs
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Disclosed herein are 4′-azido-substituted nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of 4′-azido-substituted nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a 4′-azido-substituted nucleoside, a nucleotide and/or an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
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Page/Page column 87; 88
(2016/06/13)
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- AZIDO NUCLEOSIDES AND NUCLEOTIDE ANALOGS
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Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of amelioratin
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- The design, synthesis, and antiviral activity of 4′-azidocytidine analogues against hepatitis C virus replication: The discovery of 4′-azidoarabinocytidine
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4′-Azidocytidine 3 (R1479) has been previously discovered as a potent and selective inhibitor of HCV replication targeting the RNA-dependent RNA polymerase of hepatitis C virus, NS5B. Here we describe the synthesis and biological evaluation of several der
- Smith, David B.,Kalayanov, Genadiy,Sund, Christian,Winqvist, Anna,Pinho, Pedro,Maltseva, Tatiana,Morisson, Veronique,Leveque, Vincent,Rajyaguru, Sonal,Pogam, Sophie Le,Najera, Isabel,Benkestock, Kurt,Zhou, Xiao-Xiong,Maag, Hans,Cammack, Nick,Martin, Joseph A.,Swallow, Steven,Johansson, Nils Gunnar,Klumpp, Klaus,Smith, Mark
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scheme or table
p. 219 - 223
(2009/10/01)
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- PROCESS FOR PREPARATION OF 4'-AZIDO CYTIDINE DERIVATIVES
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The invention relates to a novel process for the preparation of a 4'-azido cytidine of the formula (I) of a hydrate or of a pharmaceutically accepted salt thereof. The 4'-azido cytidine of formula (I) is useful for treating virus mediated diseases, particularly for treating HCV mediated diseases.
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Page/Page column 7-8
(2008/12/06)
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- Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479
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A series of 4′-substituted ribonucleoside derivatives has been prepared and evaluated for inhibition of hepatitis C virus (HCV) RNA replication in cell culture. The most potent and non-cytotoxic derivative was compound 28 (4′-azidocytidine, R1479) with an
- Smith, David B.,Martin, Joseph A.,Klumpp, Klaus,Baker, Stewart J.,Blomgren, Peter A.,Devos, Rene,Granycome, Caroline,Hang, Julie,Hobbs, Christopher J.,Jiang, Wen-Rong,Laxton, Carl,Pogam, Sophie Le,Leveque, Vincent,Ma, Han,Maile, Graham,Merrett, John H.,Pichota, Arkadius,Sarma, Keshab,Smith, Mark,Swallow, Steven,Symons, Julian,Vesey, David,Najera, Isabel,Cammack, Nick
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p. 2570 - 2576
(2008/02/01)
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- 4'-substituted nucleoside derivatives as inhibitors of HCV RNA replication
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The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula wherein the symbols are as defined in the specification, and of pharmaceutically a
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