- Carboline-3-carboxylic acid modified related sequences of Ala-Arg-Pro-Ala-Lys, their synthesis and use as thromobolytic agent
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The present invention relates to the protected intermediates and the deprotected products of P6A, related to the protected pseudopeptides introducing the protected intermediateds of P6A to 3S-(2-Boc)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid and the deprotected pseudopeptides, related to the protected pseudopeptides introducing the protected intermediateds of P6A to 3S-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester, related to the methods for their preparation, and related to their use as the thrombolytic agents.
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Page/Page column 15
(2010/02/11)
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- Synthesis and thrombolytic activity of pseudopeptides related to fibrinogen fragment
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Two kinds of linkers consisting of 3-(S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, ARPAK, GRPAK and QRPAK were synthesized. The thrombolytic activities in vivo indicated that the coupling position of 3-(S)-1,2,3,4-tetrahydro-β-carboline-3-carboxyl
- Wu, Yanfen,Zhao, Ming,Wang, Chao,Peng, Shiqi
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p. 2331 - 2333
(2007/10/03)
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