- Laser Induced Fluorometric Analysis of Drugs
-
Laser induction of molecular fluorescence was investigated for the analysis of intrinsically fluorescent compounds such as quinine sulfate, salicylic acid, caprofen (a carbazole), 2-methoxy-11-oxo-11H-pyrido-quinazoline-8-carboxylic acid, and fluorescent derivatives of nonfluorescent compounds such as the quinazoline produced by the photolysis of demoxepan, the 9-acridanone derivative of flurazepam, and the fluorescamine (Fluram) derivative of amphetamine.The sensitivity limit of reliable quantitation utilizing laser-induced fluorescence was equal to or better than that obtained by a conventional spectrofluorometer.
- Strojny, Norman,de Silva, Arthur J. F.
-
-
Read Online
- 4-ARYLQUINAZOLINE DERIVATIVES AS INHIBITORS OF METHIONINE ADENOSYLTRANSFERASE 2A
-
The invention relates to certain derivatives of 4-arylquinazoline formula (I) which are inhibitors of methionine adenosyltransferase 2A (MAT2A). The invention also relates to pharmaceutical compositions comprising such compounds and methods of treating diseases that can be treated by inhibition of MAT2A such as cancer, including cancers characterized by reduced or no activity of methylthioadenosine phosphorylase (MTAP).
- -
-
Paragraph 0228
(2021/12/31)
-
- Biomimetic Asymmetric Reduction of Quinazolinones with Chiral and Regenerable NAD(P)H Models
-
A facile approach to chiral dihydroquinazolinone derivatives has been described via biomimetic asymmetric reduction of quinazolinones with chiral and regenerable NAD(P)H models. The utility of this method was demonstrated by a concise synthesis of the bromodomain protein divalent inhibitor.
- Zhao, Zi-Biao,Li, Xiang,Wu, Bo,Zhou, Yong-Gui
-
supporting information
p. 714 - 718
(2020/05/04)
-
- Synthesis of dimeric quinazolin-2-one, 1,4-benzodiazepin-2-one, and isoalloxazine compounds as inhibitors of amyloid peptides association
-
The synthesis of dimeric compounds derived from quinazolin-2-one and 1,4-benzodiazepin-2-one possessing a piperazine or homopiperazine spacer was investigated. In addition, a piperazine spacered bis-isoalloxazine and a bis-riboflavin compound were prepared and their ability to interrupt the association of prion proteins and Alzheimer-specific Aβ peptides was investigated using a fast screening system based on flow cytometry. The bis-isoalloxazine 14 was identified as a new lead structure.
- Barthel, Alexander,Trieschmann, Lothar,Stroehl, Dieter,Kluge, Ralph,Boehm, Gerald,Csuk, Rene
-
experimental part
p. 445 - 452
(2009/12/05)
-
- SUBSTANCE CAPABLE OF INHIBITING CYTOKININ SIGNALING
-
Disclosed are: a substance which has an activity of inhibiting the intracellular signaling from a plant-derived cytokinin receptor and which can control the growth or differentiation of a plant. Also, disclose is a method for searching for a chemical subs
- -
-
Page/Page column 35
(2009/09/28)
-
- Process for catalyzing the oxidation of organic compounds
-
Oxidation of organic compounds is catalyzed by addition of a catalytic amount of a metalloporphyrin in a non-reactive aprotic solvent.
- -
-
Page column 6-8
(2008/06/13)
-
- Antiarrhythmic active amidinohydrazones of substituted benzophenones. Part 5: Investigations on the stability of (Z)-2-amino-5-chlorobenzophenonamidinohydrazone acetate in solution
-
The aqueous solution of the title compound can be used for injection for one year if it is stored at room temperature and under light protection. Under these conditions 8% of the E-isomer are produced. The reaction is reversible at day light. Red coloured products of decomposition are formed by long lasting influence of light. At higher temperatures or at sterilisation several products of decomposition are formed which structure is elucidated. For these decomposition a scheme is proposed.
- Schleuder,Richter,Keckeis,Jira
-
-
- The behaviour of 2-alkylamino- or dialkylamino-derivatives, respectively, of 5-phenyl-1,3,4-benzotriazepines in acid solution
-
The title compounds are treated by HCl (0.1 or 5 mol*l-1, respectively) under mild or drastic conditions, respectively, and the products of the cleavage are identified.This was followed by the same investigation of the identified or expected in
- Schleuder, M.,Richter, P.,Brandner, Anke,Morgenstern O.
-
p. 259 - 260
(2007/10/02)
-
- SYNTHESIS OF QUINAZOLINES
-
Grignard reagents reacted with 2-aminobenzonitrile to give the intermediate (10), which readily could be cyclized to quinazolines by reaction with carbonyl compounds (e.g. acid chlorides, anhydrides, formates and oxalates).The intermediate (10) and aldehy
- Bergman, Jan,Brynolf, Anna,Elman, Bjoern,Vuorinen, Eino
-
p. 3697 - 3706
(2007/10/02)
-
- Process for preparing quinazolinone oxides
-
Improved process for the preparation of 6-substituted-4-phenylquinazolinone 3-oxides. Such compounds are useful as intermediates in the preparation of 3-fluorobenzodiazepines, which are useful as tranquilizers, muscle relaxants and sedatives.
- -
-
-
- Production of quinazolinone compounds
-
2(1H)-Quinazolinone derivatives, which are useful as anti-inflammatory agents, are prepared by heating or hydrolyzing an acylurea derivative. The acylurea derivative can be prepared by either reacting an indole derivative with an oxidizing agent or reacti
- -
-
-
- Process for preparing quinazolines
-
Quinazoline derivatives which have anti-inflammatory, antiviral, uricosuric activities are prepared by reacting an indole-2-carbonylazide derivative with an oxidizing agent under mild conditions.
- -
-
-
