- Synthesis, Structure, and Properties of Amino-Substituted Benzhydrylium Ions – A Link between Ordinary Carbocations and Neutral Electrophiles
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Optimized synthetic procedures for the straightforward access to eleven amino-substituted diarylmethylium tetrafluoroborates are described. These benzhydrylium ions cover a range of seven orders of magnitude in electrophilicity and provide a link between ordinary carbocations and neutral electrophiles. Five of these highly stabilized benzhydrylium tetrafluoroborates were characterized by single-crystal X-ray crystallography. While the experimentally determined bond lengths and angles in the solid state perfectly agree with those calculated by DFT methods for the gas phase and aqueous solution, crystal packing accounts for large differences in the twist angles of the aryl groups found in the solid state as compared to calculated structures.
- Mayer, Robert J.,Hampel, Nathalie,Mayer, Peter,Ofial, Armin R.,Mayr, Herbert
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p. 412 - 421
(2018/09/14)
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- COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
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The present invention relates to pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound or pyrrolidine-2,5-dione compound of the present invention.
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Page/Page column 43
(2009/03/07)
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- 1H and 13C studies of para-substituted benzaldoximes for evaluation of the electron donor properties of substituted amino groups
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1H and 13C NMR spectra of seventeen (E)-benzaldoximes and three acetophenone oximes, both carrying substituted p-amino groups, have been recorded and discussed from the point of view of substituent effect.The resonance effect of these substituents is not transmitted strongly to CH=NOH group.However, it is found that the chemical shift of Cpara depends linearly on ?R0 values.This dependence has been used to calculate the resonance substituent constants for the less common amino groups and the 1-pyrrolidine group is found to be the most powerful electron donor among the substituents studied.
- Gawinecki, Ryszard,Kolehmainen, Erkki,Kauppinen, Reijo
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- Fischer indolization of N(α)-alkyl-2-allylphenylhydrazones
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Fischer indolization of the hydrazones of 8-allyl-1-amino-1,2,3,4-tetrahydroquinoline and related compounds was investigated. Fischer indolization induced Cope rearrangement of the allyl group and acid-catalyzed intramolecular cycloaddition between the hydrazonyl group and the vinyl group. The base treatment of the latter reaction product caused eliminative ring-opening of the adduct and led to the formation of an indoline skeleton bearing a 2-ketoalkyl group at the C-2 position.
- Katayama,Takatsu,Takeuchi,Yamagiwa
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p. 816 - 821
(2007/10/02)
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