- Titanium salalen catalysts based on cis-1,2-diaminocyclohexane: Enantioselective epoxidation of terminal non-conjugated olefins with H 2O2
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Terminal, non-conjugated olefins, such as 1-octene, are difficult to epoxidize asymmetrically. Ti salalen complexes based on cis-1,2- diaminocyclohexane catalyze this demanding reaction giving high yields and enantioselectivities (up to 95 % ee), with H2O2 as the oxidant. The X-ray structures of the μ-oxo and peroxo complexes shed light on the coordination behavior of this novel class of ligands.
- Berkessel, Albrecht,Guenther, Thomas,Wang, Qifang,Neudoerfl, Joerg-M.
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supporting information
p. 8467 - 8471
(2013/09/02)
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- Synthesis and antioxidant properties of sodium S-[3-(hydroxyaryl)propyl] thiosulfates and [3-(hydroxyaryl)propane]-1-sulfonates
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Sodium S-[3-(hydroxyaryl)propyl] thiosulfates and [3-(hydroxyaryl)propane]- 1-sulfonates with various spatial hindrance of their phenolic OH groups were synthesized from dialkylphenols via a number of intermediate products. On a model reaction of oxidation of methyl oleate in aqueous sodium dodecyl sulfate, the rate constants of the interaction of the synthesized compounds with lipoperoxide radicals were determined.
- Oleynik,Kuprina,Pevneva,Markov,Kandalintseva,Prosenko,Grigor'ev
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p. 1135 - 1143
(2008/09/17)
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- ALKYLATION OF HYDROXYARENES WITH OLEFINS, ALCOHOLS AND ETHERS IN IONIC LIQUIDS
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Hydroxyarenes are alkylated using an ionic liquid catalyst system with olefins, alcohols, or ethers as alkylating agents. The ionic liquid catalyst system comprises chloroindate (III) anions. The reactions may be conducted at moderate temperatures and pressures to yield commercially relevant alkylated hydroxyarene compounds.
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Page/Page column 18-19
(2008/06/13)
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- Non-catalyzed C-alkylation of phenols with cyclic secondary alkyl bromides
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C-Alkylations of phenol with 1-chloro and 1-bromoadamantane, 2-bromoadamantane, cyclohexyl bromide and exo-2-bromonorbornane, and C-alkylations of para-substituted phenol derivatives with 2-bromoadamantane are described.
- Arredondo, Yolanda,Moreno-Manas, Marcial,Pleixats, Roser
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p. 3885 - 3895
(2007/10/03)
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- Intramolecular Arene Hydrogenation at Niobium Metal Centres: Stereochemical Consequences
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Selective hydrogenation of 2,6-diphenylphenoxide to 2,6-dicyclohexylphenoxide ligands takes place at niobium(v) metal centres.
- Steffey, Bryan D.,Rothwell, Ian P.
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p. 213 - 215
(2007/10/02)
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- KINETICS AND MECHANISM OF THE ALKYLATION OF PHENOL WITH CYCLOHEXENE IN THE PRESENCE OF ALUMINUM PHENOLATE
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The kinetics of the alkylation of phenol with cyclohexene in the presence of aluminum phenolate was studied.A mechanism is proposed for the ortho-alkylation of phenols by olefins, involving the intermediate formation of the ion pair -R+ at a steady concentration.The ion pair is transformed into the o-alkylphenol in the controlling stage.The alkylation rate of phenol is higher that that of 2-cyclohexylphenol, and this is due to the determining effect of the entropy factor.
- Kozlikovskii, Ya. B.,Koshchii, V. A.,Chernyaev, B. V.
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p. 909 - 913
(2007/10/02)
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- REACTION OF PHENOL WITH CYCLOHEXENE IN THE PRESENCE OF ALUMINUM PHENOLATE
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The reaction of phenol with cyclohexene in the presence of aluminum phenolate leads to a mixture of mono-, di-, and tricyclohexylphenols, in which the ortho-alkylation products predominate.Conditions were found (molar ratio of phenol, cyclohexene, and catalyst 1.0:2.1:0.1, temperature 200 deg C, reaction time 8 h) under which the yield of the desired product (2,6-dicyclohexylphenol) amounted to 65percent.
- Kozlikovskii, Ya. B.,Koshchii, V. A.
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p. 108 - 111
(2007/10/02)
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- Basic ethers of cyclohexylphenols with β blocking activity. Synthesis and pharmacological study of exaprolol
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The paper discribes the preparation and study of the pharmacological properties of the basic ethers of cyclohexylphenols. The compounds with a single cycloaliphatic radical ortho to the basic chain, and in particular the one with a cyclohexyl (exaprolol), were found to be particularly active in blocking the β adrenergic receptors, as antiarrhythmics and local anesthetics, while the introduction of a second radical or the shift of the cycloaliphatic radical to meta or para position caused the said pharmacological activities to disappear almost entirely, with the exception of the local anesthetic action.
- Carissimi,Gentili,Grumelli,Milla,Picciola,Ravenna
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p. 506 - 516
(2007/10/06)
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- Phenol transalkylation process
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Phenols having an unsubstituted ortho position are transalkylated in the ortho position by mixing them with an ortho-alpha-branched alkylphenol (e.g., 2,6-di-sec-butylphenol) and an aluminum phenoxide catalyst and heating the mixture to 100°-350°C., preferably in a closed system and in the presence of olefin corresponding in structure to the ortho-alpha-branched alkyl group.
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