Novel cyclourethane-derived HIV protease inhibitors: A ring-closing olefin metathesis based strategy
A series of novel macrocyclic urethanes incorporating a (R)-hydroxyethylamine isostere was designed and synthesized. Ring size and substituent efffects have been investigated. Cyclourethanes containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against HIV-1 protease.
Ghosh, Arun K.,Swanson, Lisa M.,Liu, Chunfeng,Hussain, Khaja Azhar,Cho, Hanna,Walters,Holland, Louis,Buthod, Jim
p. 1993 - 1996
(2007/10/03)
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