Organocatalytic Allylic Amination of Morita-Baylis-Hillman Carbonates
An organocatalytic asymmetric allylic amination of Morita-Baylis-Hillman carbonates with aromatic amines in the presence of β-isocupreidine is described. Chiral allylic amines were obtained in almost quantitative yields (90-96%) with moderate enantioselectivity. Recrystallization afforded products in good yields (45-73%) and high optical purity (82-99% ee). This method provides a facile and efficient route to obtain optically active β-lactams, including the building block of the cholesterol-lowering drug Ezetimibe.
Formánek, Bed?ich,?imek, Michal,Kamlar, Martin,Císa?ová, Ivana,Vesely, Jan
p. 907 - 920
(2019/02/10)
Ortho Effects in Organic Molecules on Electron Impact: 21 - Oxygen Transfers from the Ortho Nitro Group to Sulphur in N-Aryl-2-nitrobenzenesulphenamides and Phenyl-2-nitrophenyl Disulphide
Fragment ions arising as a result of oxygen transfer from the nito group to sulphur have been noticed in N-aryl-2-nitrobenzenesulphenamides and phenyl-2-nitrophenyl disulphide.In the case of the former a double oxygen transfer to the sulphur has been noti
Ramana, D. V.,Sundaram, N.,George, M.
p. 926 - 930
(2007/10/02)
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