- New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations
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Members of the kinesin superfamily are involved in key functions during intracellular transport and cell division. Their involvement in cell division makes certain kinesins potential targets for drug development in cancer chemotherapy. The two most advanc
- Labrière, Christophe,Talapatra, Sandeep K.,Thoret, Sylviane,Bougeret, Cécile,Kozielski, Frank,Guillou, Catherine
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p. 721 - 734
(2016/02/09)
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- Use of derivatives of indoles for the treatment of cancer
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The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.
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Page/Page column 56; 57
(2016/01/09)
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- Dissecting metabolic puzzles through isotope feeding: A novel amino acid in the biosynthetic pathway of the cruciferous phytoalexins rapalexin A and isocyalexin A
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Understanding defence pathways of plants is crucial to develop disease-resistant agronomic crops, an important element of sustainable agriculture. For this reason, natural plant defenses such as phytoalexins, involved in protecting plants against microbial pathogens, have enormous biotechnological appeal. Crucifers are economically important plants, with worldwide impact as oilseeds, vegetables of great dietetic value and even nutraceuticals. Notably, the intermediates involved in the biosynthetic pathways of unique cruciferous phytoalexins such as rapalexin A and isocyalexin A remain unknown. Toward this end, using numerous perdeuterated compounds, we have established the potential precursors of these unique phytoalexins and propose for the first time their detailed biosynthetic pathway. This pathway involves a variety of intermediates and a novel amino acid as the central piece of this complex puzzle. This work has set the stage for the discovery of enzymes and genes of the biosynthetic pathway of cruciferous phytoalexins of unique scaffolds.
- Pedras, M. Soledade C.,Yaya, Estifanos E.
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p. 1149 - 1166
(2013/03/29)
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- Use of derivatives of indoles for the treatment of cancer
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The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.
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- Phytoalexins from Thlaspi arvense, a wild crucifer resistant to virulent Leptosphaeria maculans: Structures, syntheses and antifungal activity
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Phytoalexins are inducible chemical defenses produced by plants in response to diverse forms of stress, including microbial attack. Our search for phytoalexins from cruciferous plants resistant to economically important fungal diseases led us to examine s
- Pedras,Chumala,Suchy
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p. 949 - 956
(2007/10/03)
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- Simple one step syntheses of indole-3-acetonitriles from indole-3-carboxaldehydes
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One step conversion method of indole-3-carboxaldehydes into indole-3-acetonitriles is developed. Applying the method, 4-nitro- (7 a), 4-phenyl-(7 b), 4-iodo- (7 c), 4-methoxy- (7 d), and 4-benzyloxyindole-3-acetonitrile (7 e) are available in two steps from indole-3-carboxaldehyde (4).
- Yamada, Fumio,Hashizume, Tomoko,Somei, Masanori
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p. 509 - 516
(2007/10/03)
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- A SYNTHESIS METHOD OF INDOLE-3-METHANAMINE AND/OR GRAMINE FROM INDOLE-3-CARBOXALDEHYDE, AND ITS APPLICATION FOR THE SYNTHESES OF BRASSININ, ITS 4-SUBSTITUTED ANALOGS, AND 1,3,4,5-TETRAHYDROPYRROLOQUINOLINE
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Simple conversion method of indole-3-carboxaldehyde into gramine and/or indole-3-methanamine was developed.The present method realized short step syntheses of brassinin, 4-iodo-, methoxy-, 4-methoxy, and 4-nitrobrassinin, 4-methoxyindole-3-acetonitrile, and 1,3,4,5-tetrahydropyrroloquinoline.
- Yamada, Fumio,Kobayashi, Kensuke,Shimizu, Aya,Aoki, Naokatsu,Somei, Masanori
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p. 2783 - 2804
(2007/10/02)
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- The Alkaloids of Picrasma javanica
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Extraction of Picrasma javanica Bl. (Simarubaceae) has yielded two new β-carboline alkaloids, 1-ethenyl-4-methoxy-9H-pyrido-indol-5-ol (5-hydroxydehydrocrenatine) (4) and 1-ethyl-4-methoxy-9H-pyridoindol-5-ol (5-hydroxycrenatine) (5), the st
- Arbain, Dayar,Sargent, Melvyn V.
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p. 1527 - 1536
(2007/10/02)
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- RING OXYGENATED INDOLE GLUCOSINOLATES OF BRASSICA SPECIES
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Key Word Index - Brassica napus subsp. napobrassica; Brassica napus subsp. oleifera; Cruciferae; swede; rape; structural confirmation; indole glucosinolates. - Detailed chemical, degradative and spectroscopic analysis of two ring oxygenated indole glucosinolates isolated from Brassica species has confirmed these to be substituted in 4- rather than the 5-position, although the latter had been suggested on biosynthetic grounds.
- Hanley, A. B.,Belton, P. S.,Fenwick, G. R.,Janes N. F.
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p. 598 - 600
(2007/10/02)
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