- DERMATOLOGICAL COMPOSITIONS AND METHODS
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Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.
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- Treatment of neurodegenerative diseases
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Disclosed are methods for increasing the differentiation of mammalian neuronal cells for purposes of treating neurodegenerative diseases or nerve damage by administration of various compounds including alcohols, diols and/or triols and their analogues.
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- Treatment of diseases mediated by the nitric oxide/cGMP/protein kinase G pathway
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Disclosed are methods and compositions for stimulating cellular nitric oxide (NO) synthesis, cyclic guanosine monophosphate levels (cGMP), and protein kinase G (PKG) activity for purposes of treating diseases mediated by deficiencies in the NO/cGMP/PKG signal transduction pathway, by administration of various compounds including alcohols, diols and/or triols and their analogues.
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- The acetalization of glyoxal by vicinal diols
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The structure and stereochemistry of products obtained when vicinal diols are allowed to react with glyoxal were established with the aid of 13C NMR structure relationships.Hemiacetalization yields 1,4-dioxane-2,3-diols regardless of the diol reacted.The course of acetalization depends on the structure of the diol: trans-1,2-cyclohexanediol and analogs yield only 1,4,5,8-tetraoxadecalins as acetals, whereas cis-1,2-cyclohexanediol and 1,2-ethanediol yield mixtures containing mostly 2,2'-bi-1,3-dioxolanes.The isomeric distribution of products depends on the reaction conditions.
- Sangsari, Farid Hamedi,Chastrette, Francine,Chastrette, Maurice,Blanc, Alain,Mattioda, Georges
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