Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators.
A series of 5-substituted 2-benzoylaminobenzoic acids has been synthesized and assayed for PPARalpha/gamma activity. Both dual activators and selective PPARgamma agonists have been identified. This class of compounds was shown to activate the PPARgamma receptor through interaction with a novel binding site.
Thor, Markus,Beierlein, Katarina,Dykes, Graeme,Gustavsson, Anna Lena,Heidrich, Jessica,Jendeberg, Lena,Lindqvist, Bengt,Pegurier, Cecile,Roussel, Patrick,Slater, Martin,Svensson, Stefan,Sydow-Baeckman, Mona,Thornstroem, Ulla,Uppenberg, Jonas