- A mild and general method for the synthesis of 2-substituted-5-hydroxypyrimidines
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5-Bromopyrimidines are converted to 5-hydroxypyrimidines using a mild synthetic procedure. The method is general and can be applied to compounds containing functional groups which are not compatible with the other reagents previously available for this conversion.
- Medina, Jesus R.,Henry, Theresa A.,Axten, Jeffrey M.
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- PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS
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Novel compounds of structure Formula (I) or an enantiomer, a diastereomer, or a pharmaceutically acceptable salt thereof, wherein Z, R1, R2, R21, T1, T2, T3 and T4 are defined herein, are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the GPR119 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.
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Page/Page column 110
(2010/04/03)
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- SELECTIVE ACID HYDROLYSIS OF 2-SUBSTITUTED-5-DIMETHYLAMINOMETHYLENEAMINOPYRIMIDINES TO 5-AMINO- AND 5-HYDROXYPYRIMIDINES
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Conditions are described for the selective acid hydrolysis of 2-substituted-5-dimethylaminomethyleneaminopyrimidines in 0.2-2 M sulfuric acid, to give high yields of the corresponding 5-amino- and difficultly accessible 5-hydroxypyrimidines.
- Kizner, T. A.,Mikhaleva, M. A.,Serebryakova, E. S.
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p. 668 - 670
(2007/10/02)
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