- An unprecedented approach to 4,5-disubstituted pyrimidine derivatives by a ZnCl2-catalyzed three-component coupling reaction
-
We have developed a ZnCI2-catalyzed three-component coupling reaction involving a variety of functionalized enamines, triethyl orthoformate, and ammonium acetate, which leads to the production of 4,5-disubstituted pyrimidine derivatives in a single step. The procedure can be successfully applied to the efficient synthesis of mono- and disubstituted pyrimidine derivatives, using methyl ketone derivatives instead of enamines.
- Sasada, Toshiaki,Kobayashi, Fuminori,Sakai, Norio,Konakahara, Takeo
-
supporting information; experimental part
p. 2161 - 2164
(2009/09/28)
-
- NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
-
The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
- -
-
Page/Page column 252-253
(2008/06/13)
-
- Efficient microwave-assisted synthesis of highly functionalized pyrimidine derivatives
-
A generally applicable one-pot procedure for the rapid, easy, and diverse asymmetric functionalization of pyrimidines was developed that requires minimum efforts for the purification of the final products. 4-Amino-6-aryl-substituted pyrimidines are prepared in good yields by combined microwave-assisted amination and Suzuki-Miyaura cross-coupling reactions. The acid-mediated amination reaction affords the products as easily separable salts in 30-40 min reaction time.
- Hartung, Christian G.,Backes, Alexander C.,Felber, Beatrice,Missio, Andrea,Philipp, Alexander
-
p. 10055 - 10064
(2007/10/03)
-
- Fungicides
-
The invention provides fungicidal compounds of formula (I) or stereoisomers thereof: wherein X is CH2O; A is hydrogen; E is hydrogen; q is 1; any two of K, L and M are nitrogen and the other is CH; T is oxygen or sulfur; and Z is an optionally substituted phenyl group or an optionally substituted heterocyclyl group.
- -
-
-
- SYNTHESIS OF SUBSTITUTED 2- AND 4-HYDROXYAMINOPYRIMIDINES
-
The reaction of 2- and 4-chlorine-containing alkyl(aryl)pyrimidines with hydroxylamine was studied.It was shown that, depending on the amount of hydroxylamine , N,O-dipyrimidinylhydroxyamides or the corresponding 2- and 4-hydroxyaminopyrimidines are formed together with 2- and 4-oxodihydropyrimidines.
- Moskalenko, G. G.,Sedova, V. F..,Mamaev, V. P.
-
p. 1232 - 1236
(2007/10/02)
-
- The Chichibabin amination of 4-phenyl- and 4-tert-butyl-pyrimidine
-
During a study on the amination of 4-phenylpyrimidine in potassium amide/liquid ammonia it was found that the extent to which the SN(ANRORC) mechanism operates in the amination largely depends upon whether an ammonium salt is used in quenching the reaction.The composition of the ?-adduct mixture, the structure of the open-chain intermediates, the inhibition of the SN(ANRORC) mechanism and the course of the amination in apolar solvents have been investigated.In addition, it has been found that, in the amination of 4-tert-butylpyrimidine, the SN(ANRORC) mechanism occurs to only a very limited extent.
- Breuker, J.,Plas, H. C. van der
-
p. 367 - 372
(2007/10/02)
-