The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
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Page/Page column 519; 520
(2017/08/01)
Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR
The biphenyl amides are a novel series of p38 MAP kinase inhibitors. Structure-activity relationships of the series against p38α are discussed with reference to the X-ray crystal structure of an example. The series was optimised rapidly to a compound showing oral activity in an in vivo disease model.
Angell, Richard M.,Angell, Tony D.,Bamborough, Paul,Brown, David,Brown, Murray,Buckton, Jacky B.,Cockerill, Stuart G.,Edwards, Chris D.,Jones, Katherine L.,Longstaff, Tim,Smee, Penny A.,Smith, Kathryn J.,Somers, Don O.,Walker, Ann L.,Willson, Malcolm
p. 324 - 328
(2008/12/22)
SUBSTITUTED TRIAZOLES AS SODIUM CHANNEL BLOCKERS
Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other the
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Page/Page column 37-38
(2008/06/13)
BIARYL SUBSTITUTED TRIAZOLES AS SODIUM CHANNEL BLOCKERS
Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant com
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Page 40
(2008/06/13)
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