- A Study of the Behaviour of 2,4-Substituted Thiosemicarbazides toward Orthoesters: Formation of Mesoionic Compounds
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The reactions beetwen 2,4-disubstituted thiosemicarbazides and orthoesters in refluxing xylene led to the formation of the 1,2,4-triazoline-5-thione ring and to the 1,2,4-triazolium-5-thiolate ring. The formation of the mesoionic componds is due to rearrangement of the easily available 2,4-disubstituted thiosemicarbazides to 1,4-disubstituted thiosemicarbazides under the reaction conditions adopted. This method can be usefully used for the synthesis of mesoionic compounds, especially in the case of the 2-methyl-4-phenylthiosemicarbazide.
- Buccheri, Francesco,Cusmano, Giuseppe,Gruttadauria, Michelangelo,Noto, Renato,Werber, Giuseppe
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p. 1447 - 1451
(2007/10/03)
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- Methylation of 2-Phenylamino-1,3,4-thiadiazole. A Structure Debated
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The true identity of the 4-methyl-5-phenylimino-Δ2-1,3,4-thiadiazoline (A) has been demonstrated.The reactions, previously reported in the literature to give A have been repeated and the structure of the compounds obtained has been established.
- Buccheri, Francesco,Cusmano, Giuseppe,Noto, Renato,Rainieri, Rosina,Werber, Giuseppe
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p. 521 - 524
(2007/10/02)
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