- A new synthetic route to benzophenone derivatives
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The rearrangement reaction of 1-alkyl-2-(benzoylmethyl)pyridinium iodides 3a-d, 6 in the presence of various nucleophiles leads to 2-alkylaminobenzophenone derivatives 4a-c. Best results were achieved with alkylammonium sulfites as recyclization reagents.
- Abu-Melha, Sraa
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p. 313 - 316
(2017/08/15)
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- Nitropyridines 11.* recyclization of quaternary nitropyridinium salts into substituted nitroanilines
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Substituted nitroanilines have been obtained by the recyclization of nitropyridinium quaternary salts under the action of bases.
- Garkushenko,Poendaev,Vorontsova,Sagitullina
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experimental part
p. 470 - 481
(2012/01/13)
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- Micellar Catalysis of Organic Reactions. 18. Basic Hydrolysis of Diazepam and Some N-Alkyl Derivatives of Nitrazepam
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Kinetic and mechanistic studies of the basic hydrolysis of several benzodiazepinone drugs have been carried out in the presence of micelles of cetyltrimethylammonium bromide (CTAB) and in aqueous solution.For diazepam, a change of mechanism from initial azomethine hydrolysis in water to initial amide hydrolysis in the presence of micelles of CTAB is indicated.For nimetazepam and N-benzylnitrazepam, initial amide hydrolysis was observed both in the presence of CTAB and in water.For the latter compounds, strong catalysis (50-100) of amide hydrolysis (phase 1) by micelles of CTAB was observed, while azomethine hydrolysis (phase 2) was only very weakly catalyzed (3-4-fold).For diazepam, the catalysis was smaller (9-18-fold), but this was accompanied by a mechanistic change so that here the actual catalysis of amide hydrolysis is masked.
- Broxton, Trevor J.,Wright, Sallyanne
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p. 2965 - 2969
(2007/10/02)
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