- A bromine mi suofa synthetic method (by machine translation)
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The present invention provides a method for synthesis of bromine mi suofa, belongs to the technical field of drug synthesis, comprising the following steps: S1, in order to α - bromo isovaler ic acid as the raw material, in order to N, N - dimethyl formamide catalytic, adds by drops the chlorination sulfoxide solvent, reaction to obtain the α - bromo different pivaloyl chloride; S2, to S1 obtained in the bromo different α - pivaloyl chloride react with urea, condense and get [...]-cutting crude; S3, refining to obtain [...]-cutting works. The present invention provides a method of synthesis of bromine mi suofa, can effectively avoid the generation of chlorinated by-products, simple process flow, the requirements for apparatus is relatively low, the yield of the product and high purity, and is favorable for industrial production. (by machine translation)
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Paragraph 0026; 0030-0033; 0037-0039; 0044-0046; 0051-0053
(2018/09/08)
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